Study Results
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Basic Information
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COMPLETED
EARLY_PHASE1
9 participants
INTERVENTIONAL
2015-03-31
2016-05-31
Brief Summary
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Nutritional requirements for dietary amino acids in adults have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity.
Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than RDA based on nitrogen balance data.
Therefore, the purpose of this study is to measure the protein requirement in endurance trained adults using the IAAO technique.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Endurance trained
subjects will receive different levels of amino acids intakes varying from 0.2 to 2.8 g/kg/day.
amino acids intake
amino acids intakes will be varied at 0.2-2.8 g/kg/day
Interventions
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amino acids intake
amino acids intakes will be varied at 0.2-2.8 g/kg/day
Eligibility Criteria
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Inclusion Criteria
* Ability to perform the exercise stimulus (20 km run) on metabolic trial.
Exclusion Criteria
* Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption)
* Regular tobacco use
* Illicit drug use
18 Years
35 Years
MALE
Yes
Sponsors
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Ajinomoto Co., Inc.
INDUSTRY
University of Toronto
OTHER
Responsible Party
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Daniel Moore
Assistant Professor
References
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Kato H, Suzuki K, Bannai M, Moore DR. Protein Requirements Are Elevated in Endurance Athletes after Exercise as Determined by the Indicator Amino Acid Oxidation Method. PLoS One. 2016 Jun 20;11(6):e0157406. doi: 10.1371/journal.pone.0157406. eCollection 2016.
Other Identifiers
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IAAO-E
Identifier Type: -
Identifier Source: org_study_id
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