Effect of Non-essential Amino Acids on Protein Requirements for Endurance Athletes
NCT ID: NCT02874638
Last Updated: 2019-04-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
7 participants
INTERVENTIONAL
2016-09-30
2017-12-31
Brief Summary
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The biological value of protein depends on its amino acid composition. Essential amino acids are believed to have main role on whole body protein metabolism. However, it remains to be determined what role non-essential amino acids (NEAA) may have in regulating protein metabolism and contributing to the increased protein requirements after endurance exercise.
The indicator amino acid oxidation (IAAO) method has clarified the individual amino acid requirement in children, normal healthy adult and clinical populations. However, the IAAO method has never been utilized for assessing the effect of NEAA on protein requirements after endurance exercise.
The objective of the current study is to investigate the importance of NEAA for endurance-trained male subjects.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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BASE egg protein
0.8 g/kg/d of BASE protein provided as crystalline amino acid made after egg protein.
BASE egg protein
0.8 g/kg/d of protein provided as crystalline amino acid modeled after egg protein
BCAA-enriched egg protein
branched-chain amino acid-enriched egg protein
BCAA-enriched egg protein
BCAA-enriched egg protein provided as crystalline amino acid.
small amount of essential amino acids
small amount of essential amino acids made after egg protein, which is equivalent to the amount of essential amino acids in BASE
small amount of essential amino acids
essential amino acids modeled after egg protein, provided as crystalline amino acid, which is equivalent to the amount of essential amino acid in BASE egg protein
large amount of essential amino acids
large amount of essential amino acids made after egg protein, which is equivalent to the amount of amino acids in BCAA
large amount of essential amino acids
essential amino acids modeled after egg protein, provided as crystalline amino acid, which is equivalent to the amount of amino acid in BCAA-enriched egg protein
Interventions
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BASE egg protein
0.8 g/kg/d of protein provided as crystalline amino acid modeled after egg protein
BCAA-enriched egg protein
BCAA-enriched egg protein provided as crystalline amino acid.
small amount of essential amino acids
essential amino acids modeled after egg protein, provided as crystalline amino acid, which is equivalent to the amount of essential amino acid in BASE egg protein
large amount of essential amino acids
essential amino acids modeled after egg protein, provided as crystalline amino acid, which is equivalent to the amount of amino acid in BCAA-enriched egg protein
Eligibility Criteria
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Inclusion Criteria
* Participants who are categorized at least "very good" based on a study by Shvartz \& Reibold, in which VO2peak is used as an index. (i.e. the participants whose VO2peak is ≥57 ml/kg/min (18-24 y), ≥54 ml/kg/min (25-29 y), ≥52 ml/kg/min (30-34 y), ≥49 ml/kg/min (35-39 y)
* Ability to complete the 16-km familiarization run in session 2
Exclusion Criteria
* Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption)
* Regular tobacco use
* Illicit drug use
18 Years
40 Years
MALE
Yes
Sponsors
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Ajinomoto Co., Inc.
INDUSTRY
University of Toronto
OTHER
Responsible Party
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Daniel Moore
Assistant Professor
Principal Investigators
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Daniel Moore, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
University of Toronto
Other Identifiers
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IAAO-EA3
Identifier Type: -
Identifier Source: org_study_id
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