Essential Amino Acids Supplementation and Muscle Protein Synthesis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1/PHASE2

Total Enrollment

23 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-05-31

Study Completion Date

2010-07-31

Brief Summary

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The modern warfighter faces numerous physiological challenges including sleep deprivation, sustained intense physical activity, and caloric restriction, the combined effects of which may result in the loss of lean body mass and decreased physical performance. Dietary interventions may help preserve lean body mass and facilitate recovery from periods of intense physical demand. For example, dietary strategies that increase amino acid availability have been shown to stimulate protein synthesis in skeletal muscle following resistance exercise. Because military tasks also incorporate endurance exercise components, studies regarding the effects of increasing dietary amino acids following endurance exercise are warranted. The objectives of this study are to characterize the effect of endurance exercise on protein synthesis and breakdown as well as the ability of an essential amino acid supplement to influence skeletal muscle protein metabolism and its cellular and molecular regulation following endurance exercise.

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Detailed Description

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Conditions

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Muscle Loss Muscle Anabolism

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Muscle protein turnover and intracellular signaling at rest

Muscle protein turnover and intracellular signaling are measured at rest for comparison to post-exercise muscle metabolism.

Group Type NO_INTERVENTION

No interventions assigned to this group

Muscle metabolism after endurance exercise

Post-exercise muscle protein metabolism was measured to determine if endurance exercise affects muscle metabolism compared to rest.

Group Type ACTIVE_COMPARATOR

Essential Amino Acids

Intervention Type DIETARY_SUPPLEMENT

10 Gram Essential Amino Acid solutions with different leucine contents consumed during two identical endurance exercise trials

Endurance exercise

Intervention Type OTHER

60 minute endurance exercise session

Muscle Metabolism after endurance exercise

Muscle metabolism response to endurance exercise with essential amino acid supplementation

Group Type EXPERIMENTAL

Essential Amino Acids

Intervention Type DIETARY_SUPPLEMENT

10 Gram Essential Amino Acid solutions with different leucine contents consumed during two identical endurance exercise trials

Muscle anabolism after endurance exercise

Muscle anabolism after endurance exercise with essential amino acid supplementation.

Group Type EXPERIMENTAL

Essential Amino Acids

Intervention Type DIETARY_SUPPLEMENT

10 Gram Essential Amino Acid solutions with different leucine contents consumed during two identical endurance exercise trials

Interventions

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Essential Amino Acids

10 Gram Essential Amino Acid solutions with different leucine contents consumed during two identical endurance exercise trials

Intervention Type DIETARY_SUPPLEMENT

Endurance exercise

60 minute endurance exercise session

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Men and women aged 18 - 35 years
* Weight stable
* Recreationally active with VO2max of 40 - 50 ml/kg/min
* Refrain from taking any NSAIDS or any aspirin-containing medications
* Supervisor approval if a federal employee

Exclusion Criteria

* Disease or medication that affects macronutrient metabolism and/or the ability to participate in strenuous exercise
* Allergies to foods or medications (including, but not limited to, lidocaine or phenylalanine) to be utilized in the study
* Abnormal PT/PTT test or problems with blood clotting
* Present condition of alcoholism or other substance abuse that compromises exercise capacity
* Musculoskeletal injuries that compromise the ability to exercise
* Pregnancy

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes