Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
5 participants
INTERVENTIONAL
2015-09-30
2017-12-31
Brief Summary
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The biological value of protein depends on the amino acid composition. As liebig's law of the minimum, the protein synthesis is limited due to the lack of single rate limiting amino acid. In this case, the first rate limiting amino acid determines protein intakes to maximize the protein synthesis. Adding a small amount of rate-limiting amino acid to the diet improves the biological value of its protein diet.
The indicator amino acid oxidation (IAAO) method has clarified the individual amino acid requirement in children, normal healthy adult and clinical populations. however, the IAAO method has never been utilized for determining the first rate limiting amino acid.
Therefore, the purpose of this study is to address of IAAO method to be applied for determining the rate-limiting amino acid in endurance athlete.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Study Groups
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Base protein
0.8 g/kg/d of protein provided as crystalline amino acid made after egg protein.
Base protein
0.8 g/kg/d of protein provided as crystalline amino acid modeled after egg protein
Sufficient protein
1.75 g/kg/d protein provided as crystalline amino acid made after egg protein.
Sufficient protein
1.75 g/kg/d protein provided as crystalline amino acid modeled after egg protein.
Base + BCAA
Base protein intake + Branched chain amino acids
Base protein
0.8 g/kg/d of protein provided as crystalline amino acid modeled after egg protein
Branched chain amino acids
Branched chain amino acids modeled after egg protein.
Base + EAA
Base protein intake + essential amino acids.
Base protein
0.8 g/kg/d of protein provided as crystalline amino acid modeled after egg protein
Essential amino acids
Essential amino acids modeled after egg protein.
Base + NEAA
Base protein intake + non essential amino acids
Base protein
0.8 g/kg/d of protein provided as crystalline amino acid modeled after egg protein
Non essential amino acids
Non essential amino acids modeled after egg protein.
Interventions
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Base protein
0.8 g/kg/d of protein provided as crystalline amino acid modeled after egg protein
Sufficient protein
1.75 g/kg/d protein provided as crystalline amino acid modeled after egg protein.
Branched chain amino acids
Branched chain amino acids modeled after egg protein.
Essential amino acids
Essential amino acids modeled after egg protein.
Non essential amino acids
Non essential amino acids modeled after egg protein.
Eligibility Criteria
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Inclusion Criteria
* Ability to perform the exercise stimulus (20 km run) on metabolic trial.
Exclusion Criteria
* Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption)
* Regular tobacco use
* Illicit drug use
18 Years
35 Years
MALE
Yes
Sponsors
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University of Toronto
OTHER
Responsible Party
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Daniel Moore
Assistant professaor
References
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Kato H, Suzuki K, Bannai M, Moore DR. Branched-Chain Amino Acids Are the Primary Limiting Amino Acids in the Diets of Endurance-Trained Men after a Bout of Prolonged Exercise. J Nutr. 2018 Jun 1;148(6):925-931. doi: 10.1093/jn/nxy048.
Other Identifiers
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IAAO-EA
Identifier Type: -
Identifier Source: org_study_id
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