Effect of Branched-chain Amino Acid Supplementation on Muscle Damage
NCT ID: NCT03766815
Last Updated: 2019-10-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
78 participants
INTERVENTIONAL
2019-10-01
2019-12-31
Brief Summary
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Detailed Description
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Three treatment groups (n=26) will be randomly assigned to be supplemented with either 200mg BCAA/kg/day (BCAA200), 400mg BCAA/kg/day (BCAA400) or placebo (fiber supplement; PL). Supplements will be provided in jelly in a single blind fashion to be ingested 1hour after each of the three main daily meals for 18days. Anthropometric measurements (body weight, lean mass, height), body temperature, ultrasound (US), strength assessment (maximal voluntary contraction, MVC), resting metabolic rate (RMR), rate of perceived exertion (RPE), delayed onset of muscle soreness (DOMS) and blood samples (duplicates; myoglobin; BCAA) will be collected before, during and after the supplementation period at different time points (see appendix for the above tables). Repeated-bout effect (RBE) on both arms will be measured 7 days after the damage inducing session.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
SINGLE
Study Groups
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Placebo
Fiber supplement mixed with jelly will be ingested for 18 days with participants performing elbow eccentric contractions as a muscle damaging exercise on the 12th-day of supplementation.
Placebo
Fiber supplement jelly for 18 days.
Muscle damaging exercise
Participants will be asked to perform muscle damaging elbow eccentric contraction exercise at 120% of 1RM for three sets of 15 repetitions with the dominant arm at maximal effort on a Biodex machine with a 3 minute rest period between each set.
BCAA 200mg/kg/day
Branched-chain amino acid supplement mixed with jelly will be ingested for 18 days. The amount of supplement provided will be based on body weight (200mg/kg/day) with participants performing elbow eccentric contractions as a muscle damaging exercise on the 12th-day of supplementation.
BCAA 200mg/kg/day
BCAA supplement based on 200mg/kg/day for 18 days.
Muscle damaging exercise
Participants will be asked to perform muscle damaging elbow eccentric contraction exercise at 120% of 1RM for three sets of 15 repetitions with the dominant arm at maximal effort on a Biodex machine with a 3 minute rest period between each set.
BCAA 400mg/kg/day
Branched-chain amino acid supplement mixed with jelly will be ingested for 18 days. The amount of supplement provided will be based on body weight (400mg/kg/day) with participants performing elbow eccentric contractions as a muscle damaging exercise on the 12th-day of supplementation.
BCAA 400mg/kg/day
BCAA supplement based on 400mg/kg/day for 18 days.
Muscle damaging exercise
Participants will be asked to perform muscle damaging elbow eccentric contraction exercise at 120% of 1RM for three sets of 15 repetitions with the dominant arm at maximal effort on a Biodex machine with a 3 minute rest period between each set.
Interventions
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BCAA 200mg/kg/day
BCAA supplement based on 200mg/kg/day for 18 days.
Placebo
Fiber supplement jelly for 18 days.
BCAA 400mg/kg/day
BCAA supplement based on 400mg/kg/day for 18 days.
Muscle damaging exercise
Participants will be asked to perform muscle damaging elbow eccentric contraction exercise at 120% of 1RM for three sets of 15 repetitions with the dominant arm at maximal effort on a Biodex machine with a 3 minute rest period between each set.
Eligibility Criteria
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Inclusion Criteria
* Endurance trained athletes
* Weekly exercise duration is less than 150minutes but more than 30 minutes
Exclusion Criteria
* Diabetic
* Have been performing resistance trainings
* Have been taking protein supplement
* Have been consuming a high level of protein in the regular diet
* Have been taking omega-three and vitamin E supplements
* Have been taking anabolic Steroids
* Have been taking regular medications
* Have cardiovascular Disease
* Have a history of joint \& Muscle Injuries
* Females with irregular Menstrual Cycle
18 Years
40 Years
ALL
Yes
Sponsors
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Western University, Canada
OTHER
Responsible Party
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Peter Lemon
Principal Investigator
Principal Investigators
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Peter Lemon, PhD
Role: PRINCIPAL_INVESTIGATOR
Western University
Locations
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Exercise Nutrition Laboratory (Western University)
London, Ontario, Canada
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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113281
Identifier Type: -
Identifier Source: org_study_id
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