Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Signaling Pathways

NCT ID: NCT01350427

Last Updated: 2013-02-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-08-31

Study Completion Date

2013-02-28

Brief Summary

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This study aims to evaluate the effects of leucine and branched-chain amino acids supplementation on skeletal muscle remodeling signaling pathways induced by resistance exercise.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Leucine

Group Type EXPERIMENTAL

Leucine supplementation

Intervention Type DIETARY_SUPPLEMENT

1 bout of resistance exercise and supplementation of 4.0 g of leucine + 5.6 g of alanine

BCAA

Group Type EXPERIMENTAL

BCAA supplementation

Intervention Type DIETARY_SUPPLEMENT

1 bout of resistance exercise and supplementation of 4.0 g of leucine + 2.8 g of isoleucine + 2.8 g of valine

Placebo

Group Type PLACEBO_COMPARATOR

Alanine supplementation

Intervention Type DIETARY_SUPPLEMENT

1 bout of resistance exercise and supplementation of 9.6 g of alanine

Interventions

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Leucine supplementation

1 bout of resistance exercise and supplementation of 4.0 g of leucine + 5.6 g of alanine

Intervention Type DIETARY_SUPPLEMENT

BCAA supplementation

1 bout of resistance exercise and supplementation of 4.0 g of leucine + 2.8 g of isoleucine + 2.8 g of valine

Intervention Type DIETARY_SUPPLEMENT

Alanine supplementation

1 bout of resistance exercise and supplementation of 9.6 g of alanine

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Sedentaries
* Must be able to exercise
* Must be able to swallow tablets

Exclusion Criteria

* Use of nutritional supplements
* Use of anti-inflammatory drugs
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Sao Paulo

OTHER

Sponsor Role lead

Responsible Party

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Humberto Nicastro

PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Claudia R da Luz, Master Student

Role: PRINCIPAL_INVESTIGATOR

University of Sao Paulo

Locations

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University of São Paulo - School of Physical Education and Sports

São Paulo, São Paulo, Brazil

Site Status

Countries

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Brazil

Other Identifiers

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2011/04690-6

Identifier Type: -

Identifier Source: org_study_id

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