Leucine and Beta-hydroxy-beta-methylbutyrate (HMB) as Anabolic Nutrients After 36 Hours of Fasting
NCT ID: NCT01840098
Last Updated: 2014-11-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
8 participants
INTERVENTIONAL
2014-01-31
2014-10-31
Brief Summary
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Fasting (36 hours) creates a catabolic state that is comparable with the catabolic state seen in acute illness.
This study is a randomized, placebo cross-over study investigating 8 healthy men on 4 separated days (at least 3 weeks between trials).
* High leucine content drink
* Low leucine content drink
* Low leucine content drink + HMB
* Carbohydrate (isocaloric)
The investigators hypothesize that these nutritional supplements may counteract catabolic processes in different ways and degrees.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
SINGLE
Study Groups
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control
Isocaloric carbohydrate drink
Control/carbohydrate
36 hour fasting
low leucine content drink
A soy protein drink
low leucine content drink
36 hour fasting
high content of leucine drink
A whey protein drink
high leucine content drink
36 hour fasting
low leucine content + HMB drink
Soy protein drink added HMB
low leucine + HMB drink
36 hour fasting
Interventions
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low leucine content drink
high leucine content drink
low leucine + HMB drink
Control/carbohydrate
36 hour fasting
Eligibility Criteria
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Inclusion Criteria
* 20\<BMI\<30
* Age \> 20 years old
* Written consent before starting the study
Exclusion Criteria
* Diabetes
* Epilepsy
* Infection
* Immune defects
* Heart disease
* Dysregulated hypertension
* Participating in other trials using radioactive tracers or x-rays the last year.
20 Years
MALE
Yes
Sponsors
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University of Aarhus
OTHER
Responsible Party
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Nikolaj Fibiger Rittig
MD (medical graduate) and Ph.d.-student
Locations
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Department of Internal Medicine and Endocrinology, Aarhus Universitetshospital
Aarhus C, , Denmark
Countries
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References
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Pedersen MGB, Lauritzen ES, Svart MV, Stoy J, Sondergaard E, Thomsen HH, Kampmann U, Bjerre M, Jessen N, Moller N, Rittig N. Nutrient sensing: LEAP2 concentration in response to fasting, glucose, lactate, and beta-hydroxybutyrate in healthy young males. Am J Clin Nutr. 2023 Dec;118(6):1091-1098. doi: 10.1016/j.ajcnut.2023.10.007. Epub 2023 Oct 14.
Rittig N, Bach E, Thomsen HH, Moller AB, Hansen J, Johannsen M, Jensen E, Serena A, Jorgensen JO, Richelsen B, Jessen N, Moller N. Anabolic effects of leucine-rich whey protein, carbohydrate, and soy protein with and without beta-hydroxy-beta-methylbutyrate (HMB) during fasting-induced catabolism: A human randomized crossover trial. Clin Nutr. 2017 Jun;36(3):697-705. doi: 10.1016/j.clnu.2016.05.004. Epub 2016 May 25.
Other Identifiers
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1-10-72-63-13
Identifier Type: -
Identifier Source: org_study_id
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