Effects of Protein Supplementation on Lean Body Mass Recovery From Extreme Military Training
NCT ID: NCT02057094
Last Updated: 2017-07-21
Study Results
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Basic Information
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COMPLETED
NA
71 participants
INTERVENTIONAL
2014-01-31
2015-03-31
Brief Summary
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SERE school may be an ideal setting to assess nutritional interventions that promote recovery from severe military operational stress, and identify innate or experiential variables that may lead to increased levels of resilience in Warfighters. Our laboratory has recently demonstrated the detrimental effects and stressful nature of SERE. Heart rates and stress-related hormones increased dramatically, with concomitant reductions in circulating anabolic hormones. Additionally, SERE causes significant weight loss (15-20 lbs), which probably included lean body mass. The effects of severe operational stress induced by SERE, particularly the loss of lean mass, may degrade physical performance, increase injury risk, and compromise military readiness. Under controlled laboratory conditions, consuming high protein diets or supplemental high-quality protein promotes muscle protein retention, enhances muscle protein synthesis, and protects lean body mass in response to stress. Whether consuming supplemental protein promotes lean mass recovery and physiological resilience following a 'real-world' military stress has not been determined. Further, the level of supplemental protein necessary to optimize recovery from extreme military operational stress has not been elucidated.
Up to 90 US Marines will be enrolled in a 46-day double-blind, placebo-controlled trial. Using complex body composition measurements, kinetic modeling of human metabolism, blood sampling and cognitive and nutrition questionnaires, the consequences of SERE and the efficacy of protein recovery nutrition on lean mass accretion and Warfighter resilience will be assessed.
We hypothesize that consuming a specially formulated, high-quality supplemental protein ration item will speed recovery of lean body mass, physiological, and psychological resilience following extreme military operational stress.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
DOUBLE
Study Groups
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Control
Dining facility recovery feeding only, no supplemental protein consumed (an isoenergetic, carbohydrate supplement will be consumed by those assigned to the Control group)
Protein, High-Protein, and Control
Protein
Consume dining facility food with:
2, 20 g whey protein supplements daily (for \~27 days)
1, 40 g casein protein supplement daily (for \~27 days)
Protein, High-Protein, and Control
High-Protein
Consume dining facility food with:
2, 40 g whey protein supplements daily (\~27 days)
1, 50 g casein protein supplement daily (\~27 days)
Protein, High-Protein, and Control
Interventions
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Protein, High-Protein, and Control
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
MALE
Yes
Sponsors
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United States Army Research Institute of Environmental Medicine
FED
Responsible Party
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Principal Investigators
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Stefan M Pasiakos, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
USARIEM Military Nutrition Division
Locations
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US Marine SERE School
Marine Corps Base Camp Lejeune, North Carolina, United States
Countries
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References
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Berryman CE, Sepowitz JJ, McClung HL, Lieberman HR, Farina EK, McClung JP, Ferrando AA, Pasiakos SM. Supplementing an energy adequate, higher protein diet with protein does not enhance fat-free mass restoration after short-term severe negative energy balance. J Appl Physiol (1985). 2017 Jun 1;122(6):1485-1493. doi: 10.1152/japplphysiol.01039.2016. Epub 2017 Apr 6.
Berryman CE, McClung HL, Sepowitz JJ, Gaffney-Stomberg E, Ferrando AA, McClung JP, Pasiakos SM. Testosterone status following short-term, severe energy deficit is associated with fat-free mass loss in U.S. Marines. Physiol Rep. 2022 Sep;10(18):e15461. doi: 10.14814/phy2.15461.
Other Identifiers
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14-02H
Identifier Type: -
Identifier Source: org_study_id
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