Mycoprotein and Pea Protein Blend and Muscle Protein Synthetic Response

NCT ID: NCT04894747

Last Updated: 2023-03-22

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 33 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-05-01
• Study Completion Date: 2022-06-15

Brief Summary

Dietary protein is vital for the preservation of health and optimal adaptation to training. Plant proteins are considered inferior to animal proteins with respect to their ability to stimulate an acute muscle building response and therefore support long-term muscle reconditioning. Pea protein is a highly commercially available plant proteins source (available as supplements, food ingredients etc.), yet there is no research investigating its ability to stimulate a muscle building response. The investigators aim to assess the effect of consuming pea protein on muscle protein synthesis rates and compare these results to mycoprotein, a source known to elicit a robust anabolic response.

Pea protein is lower in some of the essential amino acids, namely methionine, which could mean it is less effective compared with mycoprotein which has a more complete amino acid profile. So in addition to comparing pea with mycoprotein, the investigators also want to compare to a blend of pea and mycoprotein to see if replenishing the amino acid content in pea 'rescues' the anabolic response.

Conditions

Muscle Protein Synthesis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: TRIPLE

Study Groups

Mycoprotein

Bolus ingestion of mycoprotein providing 25g of protein.

Group Type: EXPERIMENTAL

Bolus ingestion of protein

Intervention Type: DIETARY_SUPPLEMENT

Ingestion of 25g of protein

Pea protein

Bolus ingestion of pea protein providing 25g of protein.

Group Type: EXPERIMENTAL

Bolus ingestion of protein

Intervention Type: DIETARY_SUPPLEMENT

Ingestion of 25g of protein

Mycoprotein/pea protein dry blend

Bolus ingestion of mycoprotein/pea protein dry blend providing 25g of protein.

Group Type: EXPERIMENTAL

Bolus ingestion of protein

Intervention Type: DIETARY_SUPPLEMENT

Ingestion of 25g of protein

Interventions

Bolus ingestion of protein

Ingestion of 25g of protein

Intervention Type: DIETARY_SUPPLEMENT

Other Intervention Names

Protein ingestion

Eligibility Criteria

Inclusion Criteria

• BMI between 18 and 30
• Resistance trained

Exclusion Criteria

• Any metabolic impairment
• Smoking
• Use of over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices).
• A personal family history of epilepsy, seizures or schizophrenia.
• Allergic to Quorn/mycoprotein/edible fungi/environmental mould products.
• Any motor disorder.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Quorn

INDUSTRY

Sponsor Role: collaborator

University of Exeter

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

University of Exeter

Exeter, , United Kingdom

Countries

United Kingdom

Other Identifiers

200325_B_04UOE

Identifier Type: -

Identifier Source: org_study_id