The Effects of Whey, Rice and Potato pRotein isOlates on appeTite rEgulatIoN in Healthy Men

NCT ID: NCT04876495

Last Updated: 2021-05-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-07-20

Study Completion Date

2021-02-19

Brief Summary

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INTRODUCTION: Global protein consumption has been increasing for decades due to changes in socio-economic demographics and consumer trends towards higher protein intake, which may be related to their health benefits in performance nutrition and appetite regulation. The additional intake of protein often occurs in the form of supplements. One of the main ingredients used in sports and weight loss supplements are animal-derived proteins such as whey, which are of high quality, containing all the essential amino acids required in human nutrition with a high absorption rate. However, whey protein has a high environmental footprint, and it may contribute to insulin resistance in susceptible groups (e.g. obese, T2DM, insulin resistant, or those with sarcopenic obesity).

Rice and potato protein isolates are high-quality plant proteins containing all essential amino acids comparably to whey protein. These plant-derived proteins may provide a more sustainable and accessible alternative to animal-derived proteins for appetite regulation and weight management.

Detailed Description

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Intervention study with three treatment groups in a randomised, single-blind, triple crossover design.

Study population: Healthy male participants will receive three different isocaloric and -volumetric protein shakes prepared using whey, rice and potato protein powders on different trial days with at least a one-week washout period apart.

Biological samples (blood and saliva samples) are collected at various time points during the visit. Blood samples are collected at baseline 10 min prior (T-10), then at 30 min (T30), 60 min (T60), 120 min (T120) and at 180 min (T180) after protein shake consumption. Saliva samples are collected at baseline (T-10), then at every 30 minutes following protein shake consumption (T30, T60, T90, T120, T150, T180). In addition, pertinent questionnaires Visual Analogue Scale \[VAS\] for the assessment of satiety and VAS for the assessment of protein shakes' perception will be collected at T-10, T30, T60, T90, T120, T150, T180 and at T0, respectively

Conditions

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Appetite and General Nutritional Disorders

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

single-blind, randomised, triple crossover
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Whey protein

Whey protein isolate (45.5g total protein content)

Group Type ACTIVE_COMPARATOR

Whey protein isolate

Intervention Type DIETARY_SUPPLEMENT

Instantized BiPRO® 50g (equiv. 45.5g of total protein) presented to participants in a form of a shake.

Other ingredients in the whey protein shake:

* Tropicana Trop50 Orange Juice 207mL
* Water 43 mL
* Sucralose 0.5g

The total energy 233.47Kcal.

Participants instructed to consume the entire protein shake presented to them in 5 minutes on an empty stomach when attending the study.

Potato protein

Potato protein isolate (45.3g total protein content)

Group Type ACTIVE_COMPARATOR

Potato protein isolate

Intervention Type DIETARY_SUPPLEMENT

Solanic®100 48g (equiv. 45.3g of total protein) presented to participants in a form of a shake.

Other ingredients in the potato protein shake:

* Tropicana Trop50 Orange Juice 250mL
* Sucralose 0.5g

The total energy 233.46Kcal

Participants instructed to consume the entire protein shake presented to them in 5 minutes on an empty stomach when attending the study.

Rice protein

Rice protein isolate (45.5g total protein content)

Group Type ACTIVE_COMPARATOR

Rice protein isolate

Intervention Type DIETARY_SUPPLEMENT

Oryzatein® Silk 90 50g (equiv. 45.5g of total protein) presented to participants in a form of a shake.

Other ingredients in the rice protein shake:

* Tropicana Trop50 Orange Juice 183mL
* Water 67mL
* Sucralose 0.5g

The total energy 233.43Kcal

Participants instructed to consume the entire protein shake presented to them in 5 minutes on an empty stomach when attending the study.

Interventions

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Whey protein isolate

Instantized BiPRO® 50g (equiv. 45.5g of total protein) presented to participants in a form of a shake.

Other ingredients in the whey protein shake:

* Tropicana Trop50 Orange Juice 207mL
* Water 43 mL
* Sucralose 0.5g

The total energy 233.47Kcal.

Participants instructed to consume the entire protein shake presented to them in 5 minutes on an empty stomach when attending the study.

Intervention Type DIETARY_SUPPLEMENT

Potato protein isolate

Solanic®100 48g (equiv. 45.3g of total protein) presented to participants in a form of a shake.

Other ingredients in the potato protein shake:

* Tropicana Trop50 Orange Juice 250mL
* Sucralose 0.5g

The total energy 233.46Kcal

Participants instructed to consume the entire protein shake presented to them in 5 minutes on an empty stomach when attending the study.

Intervention Type DIETARY_SUPPLEMENT

Rice protein isolate

Oryzatein® Silk 90 50g (equiv. 45.5g of total protein) presented to participants in a form of a shake.

Other ingredients in the rice protein shake:

* Tropicana Trop50 Orange Juice 183mL
* Water 67mL
* Sucralose 0.5g

The total energy 233.43Kcal

Participants instructed to consume the entire protein shake presented to them in 5 minutes on an empty stomach when attending the study.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Males (18-65 years of age)
* Healthy subjects

Exclusion Criteria

* \<18 years or \>65 years
* Consumption of \>21 units of alcohol/week
* Dieters
* Any allergies/health issues related to items being ingested
* Any serious illnesses or those on medication
* Any illness affecting taste or appetite
* Any gastrointestinal disorders
* Any eating disorders
* Any depression/mental disorders
* Smoking
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Coventry University

OTHER

Sponsor Role collaborator

University of Westminster

OTHER

Sponsor Role lead

Responsible Party

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Mohammed Gulrez Zariwala

Professor of Translational Physiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mohammed Gulrez Zariwala, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Westminster

Locations

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University of Westminster

London, Greater London, United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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VRE1516-1375

Identifier Type: -

Identifier Source: org_study_id

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