Vegan Whey Protein for Muscle Anabolism and Post-exercise Recovery
NCT ID: NCT07119749
Last Updated: 2025-08-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
27 participants
INTERVENTIONAL
2023-09-01
2024-11-22
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
TRIPLE
Study Groups
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Vegan whey protein
3 x daily supplementation of 0.3 g per kg body mass of vegan whey protein isolate for 3 days following an acute bout of lower-body unilateral resistance exercise
Stable isotope tracer consumption
Daily consumption of oral deuterium oxide (0.3 ml per kg of lean body mass) to equilibrate in body water and become slowly incorporated into muscle protein, enabling measurement of muscle protein synthesis rates
DXA scan
Whole body DXA scan to assess lean body mass for prescription of deuterium oxide tracer
Controlled diet
Participant will be asked to consume a provided 6-day diet package that will be prepared by the research team. This package will include 3 meals per day plus snacks
Saliva sample
Obtained from participants by asking them to spit into a tube each day during the study, for 11 days in total.
Blood sample
Resting venous blood sample from a forearm vein on 6 separate occasions
Muscle biopsy
A highly experienced researcher will sample a small section of muscle (\~200 mg) from the vastus lateralis muscle under local anaesthetic (5 ml, 1% Lidocaine)
Resistance exercise
participants will complete 8 sets of 10 repetitions of unilateral eccentric knee extensions on an isokinetic dynamometer.
Isometric strength test
Bilateral isometric strength will be measured using a well-established protocol on an isokinetic dynamometer.
Supplement
Consumption of 3 supplements a day for 3 days following resistance exercise. All supplements are commercially available.
Dairy whey protein
3 x daily supplementation of 0.3 g per kg body mass of dairy whey protein isolate for 3 days following an acute bout of lower-body unilateral resistance exercise
Stable isotope tracer consumption
Daily consumption of oral deuterium oxide (0.3 ml per kg of lean body mass) to equilibrate in body water and become slowly incorporated into muscle protein, enabling measurement of muscle protein synthesis rates
DXA scan
Whole body DXA scan to assess lean body mass for prescription of deuterium oxide tracer
Controlled diet
Participant will be asked to consume a provided 6-day diet package that will be prepared by the research team. This package will include 3 meals per day plus snacks
Saliva sample
Obtained from participants by asking them to spit into a tube each day during the study, for 11 days in total.
Blood sample
Resting venous blood sample from a forearm vein on 6 separate occasions
Muscle biopsy
A highly experienced researcher will sample a small section of muscle (\~200 mg) from the vastus lateralis muscle under local anaesthetic (5 ml, 1% Lidocaine)
Resistance exercise
participants will complete 8 sets of 10 repetitions of unilateral eccentric knee extensions on an isokinetic dynamometer.
Isometric strength test
Bilateral isometric strength will be measured using a well-established protocol on an isokinetic dynamometer.
Supplement
Consumption of 3 supplements a day for 3 days following resistance exercise. All supplements are commercially available.
Carbohydrate placebo
3 x daily supplementation of isocaloric carbohydrate placebo for 3 days following an acute bout of lower-body unilateral resistance exercise
Stable isotope tracer consumption
Daily consumption of oral deuterium oxide (0.3 ml per kg of lean body mass) to equilibrate in body water and become slowly incorporated into muscle protein, enabling measurement of muscle protein synthesis rates
DXA scan
Whole body DXA scan to assess lean body mass for prescription of deuterium oxide tracer
Controlled diet
Participant will be asked to consume a provided 6-day diet package that will be prepared by the research team. This package will include 3 meals per day plus snacks
Saliva sample
Obtained from participants by asking them to spit into a tube each day during the study, for 11 days in total.
Blood sample
Resting venous blood sample from a forearm vein on 6 separate occasions
Muscle biopsy
A highly experienced researcher will sample a small section of muscle (\~200 mg) from the vastus lateralis muscle under local anaesthetic (5 ml, 1% Lidocaine)
Resistance exercise
participants will complete 8 sets of 10 repetitions of unilateral eccentric knee extensions on an isokinetic dynamometer.
Isometric strength test
Bilateral isometric strength will be measured using a well-established protocol on an isokinetic dynamometer.
Supplement
Consumption of 3 supplements a day for 3 days following resistance exercise. All supplements are commercially available.
Interventions
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Stable isotope tracer consumption
Daily consumption of oral deuterium oxide (0.3 ml per kg of lean body mass) to equilibrate in body water and become slowly incorporated into muscle protein, enabling measurement of muscle protein synthesis rates
DXA scan
Whole body DXA scan to assess lean body mass for prescription of deuterium oxide tracer
Controlled diet
Participant will be asked to consume a provided 6-day diet package that will be prepared by the research team. This package will include 3 meals per day plus snacks
Saliva sample
Obtained from participants by asking them to spit into a tube each day during the study, for 11 days in total.
Blood sample
Resting venous blood sample from a forearm vein on 6 separate occasions
Muscle biopsy
A highly experienced researcher will sample a small section of muscle (\~200 mg) from the vastus lateralis muscle under local anaesthetic (5 ml, 1% Lidocaine)
Resistance exercise
participants will complete 8 sets of 10 repetitions of unilateral eccentric knee extensions on an isokinetic dynamometer.
Isometric strength test
Bilateral isometric strength will be measured using a well-established protocol on an isokinetic dynamometer.
Supplement
Consumption of 3 supplements a day for 3 days following resistance exercise. All supplements are commercially available.
Eligibility Criteria
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Inclusion Criteria
* Healthy individuals free from metabolic and respiratory disease
* Recreationally active or trained (complete at least 150 mins of moderate physical activity, or 75 mins of vigorous physical activity per week, identify with a certain sport, intend to compete in local competition)
* Understands and is willing, able and likely to comply with all study procedures and restrictions
* Demonstrates an understanding of the study and willingness to participate, as evidenced by voluntary written informed consent
Exclusion Criteria
* Pregnancy and Breastfeeding
* Body mass index \<18.5 or \>29.9 kg/m2
* Regular participation (i.e., \>3 times weekly for the previous 3 months) in structured exercise or sport with a large eccentric component, such as trail running, soccer, basketball etc.
* Elite athletes or sports-people who compete nationally or internationally
* Habitual smokers
* History of respiratory or metabolic disease
* Any allergies or intolerances to the study materials, protein supplements and food ingredients to be used in this study. In particular, those with an allergy to lidocaine and lactose will be excluded
* Use of any medication or supplements known to affect muscle protein metabolism (e.g., beta-blockers, corticosteroids, analgesics, or non-steroidal anti-inflammatories). Additional medications and/or supplementation aids (e.g., vitamins) will be deemed inappropriate based on the PI's discretion
* Any current or history of musculoskeletal injury
* Any history of medical or surgical events that may affect the study outcomes
* Previous participation in a research-based exercise protocol designed to induce severe muscle damage in the last 6 months
* Habitual protein intakes \<0.8 g/kg body mass/day or \> 2.2 g/kg body mass/day
18 Years
40 Years
ALL
Yes
Sponsors
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University of Birmingham
OTHER
Responsible Party
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Locations
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School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham
Birmingham, West Midlands, United Kingdom
Countries
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Other Identifiers
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RG_21-198
Identifier Type: -
Identifier Source: org_study_id
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