Exploring Muscle Breakdown During Exercise Recovery

NCT ID: NCT04841772

Last Updated: 2023-03-23

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 26 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-04-08
• Study Completion Date: 2022-12-01

Brief Summary

This study will allow researchers to explore how muscle responds to heavy exercise. The researchers will characterise rates of muscle protein breakdown and synthesis 24hours after heavy exercise with a post exercise protein polyphenol or placebo supplementation. This will inform strategies to help people recover from heavy exercise.

Detailed Description

It is well known that resistance exercise increases rates of muscle protein synthesis and breakdown, with the rise in synthesis greater in magnitude and duration. The time course of rates of muscle protein synthesis increase dramatically 24-72h following eccentric exercise, even in a non-exercised control leg. This data is consistent with a much larger increase in muscle protein breakdown than previously thought. However, the response of muscle protein breakdown following damaging eccentric exercise, and its relationship with muscle protein synthesis, has not yet been elucidated. Moreover, it is unclear whether a protein and polyphenol nutritional intervention influence rates of muscle protein breakdown to accelerate recovery. This study will allow researchers to test the hypothesis that eccentric exercise increases rates of muscle protein breakdown independently of muscle contraction per se. If this hypothesis is supported, it will highlight that recovery strategies from muscle damage should also target supporting muscle protein breakdown.

Conditions

Muscle Damage; Healthy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: DOUBLE

Study Groups

Vegan Protein

Group Type: ACTIVE_COMPARATOR

Recover Vegan Protein Supplement

Intervention Type: DIETARY_SUPPLEMENT

Post exercise protein supplement (26g pea protein)

Placebo

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DIETARY_SUPPLEMENT

Post exercise placebo supplement (32g maltodextrin)

Interventions

Recover Vegan Protein Supplement

Post exercise protein supplement (26g pea protein)

Intervention Type: DIETARY_SUPPLEMENT

Placebo

Post exercise placebo supplement (32g maltodextrin)

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

• Recreationally active
• 18-40 years of age

Exclusion Criteria

• Regular and structured involvement in resistance training
• Inactive participants
• Habitual dietary protein intake <0.8g/kg bw/day and >2.0g/kg bw/day
• Regular use of nutritional supplements known to suppress inflammation or modulate protein metabolism Any diagnosed metabolic conditions (diabetes), cardiovascular disease or hypertension
• Current musculoskeletal injury
• Chronic use of anti-inflammatory medicines
• Any known disorders in muscle metabolism
• Individuals with an allergy to egg, fish, wheat or soy ingredients as the product is manufactured in a facility that contains these ingredients
• Allergy to lidocaine
• Having received or ingested a stable isotope tracer containing 15N in the past
• A personal or family history of epilepsy, seizures or schizophrenia
• Stomach bleeding or stomach ulcer
• Kidney failure
• Liver problems, such as fibrosis, cirrhosis or failure
• Crohns disease or ulcerative colitis
• Chickenpox or shingles
• Pregnant or trying to get pregnant
• Any diagnosed cardiovascular disease (e.g. deep vein thrombosis) or hypertension.
• Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes)
• Recent (within the last 6 months) or current musculoskeletal injury (leg fracture)

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Beachbody

INDUSTRY

Sponsor Role: collaborator

University of Exeter

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

University of Exeter

Exeter, Devon, United Kingdom

Countries

United Kingdom

Other Identifiers

210203-B-01

Identifier Type: -

Identifier Source: org_study_id