Protein Ingestion and Skeletal Muscle Atrophy

NCT ID: NCT03797781

Last Updated: 2020-09-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

33 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-10-31

Study Completion Date

2019-12-31

Brief Summary

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The effect of different protein intakes on skeletal muscle atrophy during short term unilateral leg immobilisation.

Detailed Description

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Conditions

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Muscle Atrophy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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High protein

Group Type EXPERIMENTAL

Lower limb immobilisation (leg brace) with varying levels of protein intake

Intervention Type OTHER

Single leg immobilisation via leg brace and crutches, the groups have different amounts of protein intake

Low protein

Group Type EXPERIMENTAL

Lower limb immobilisation (leg brace) with varying levels of protein intake

Intervention Type OTHER

Single leg immobilisation via leg brace and crutches, the groups have different amounts of protein intake

Minimum protein

Group Type EXPERIMENTAL

Lower limb immobilisation (leg brace) with varying levels of protein intake

Intervention Type OTHER

Single leg immobilisation via leg brace and crutches, the groups have different amounts of protein intake

Interventions

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Lower limb immobilisation (leg brace) with varying levels of protein intake

Single leg immobilisation via leg brace and crutches, the groups have different amounts of protein intake

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* BMI \>18 and \<28 no prescription medications or current illness.

Exclusion Criteria

* BMI \<18 and \>28 current prescription medication no history of leg injury.
* Smoker
* Medical conditions including (cardiovascular disease ((e.g. hypertension)), metabolic disease ((e.g. type 2 diabetes)), any personal or family history of deep vein thrombosis.
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Exeter

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Sport and Health Science

Exeter, Devon, United Kingdom

Site Status

Countries

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United Kingdom

References

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Kilroe SP, Fulford J, Jackman S, Holwerda A, Gijsen A, van Loon L, Wall BT. Dietary protein intake does not modulate daily myofibrillar protein synthesis rates or loss of muscle mass and function during short-term immobilization in young men: a randomized controlled trial. Am J Clin Nutr. 2021 Mar 11;113(3):548-561. doi: 10.1093/ajcn/nqaa136.

Reference Type DERIVED
PMID: 32469388 (View on PubMed)

Other Identifiers

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6500619582

Identifier Type: -

Identifier Source: org_study_id

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