The Muscle Protein Synthetic Response of Algal and Fungal Protein

NCT ID: NCT05016557

Last Updated: 2024-01-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-12-19

Study Completion Date

2022-06-24

Brief Summary

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Dietary protein intake is vital for the maintenance of skeletal muscle mass and health. The production of animal-based proteins sources is associated with growing environmental and ethical challenges. As such, sustainable alternatives are needed. Algae are sustainably produced high-protein sources and it is predicted that algae will become one of the most consumed proteins in the next decades. However, the effects of algae on the stimulation of muscle mass growth are unknown. Therefore, we aim to assess the rate of digestion and absorption, and the effects on muscle growth of two types of algae (spirulina and chlorella) when compared to a sustainable non-animal derived fungal reference protein (mycoprotein), a source known to elicit a robust anabolic response.

Detailed Description

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Conditions

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Muscle Metabolism

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Mycoprotein

Bolus ingestion of mycoprotein providing 25g protein

Group Type EXPERIMENTAL

Protein ingestion

Intervention Type DIETARY_SUPPLEMENT

Bolus ingestion of 25g protein

Spirulina

Bolus ingestion of spirulina providing 25g protein

Group Type EXPERIMENTAL

Protein ingestion

Intervention Type DIETARY_SUPPLEMENT

Bolus ingestion of 25g protein

Chlorella

Bolus ingestion of chlorella providing 25g protein

Group Type EXPERIMENTAL

Protein ingestion

Intervention Type DIETARY_SUPPLEMENT

Bolus ingestion of 25g protein

Interventions

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Protein ingestion

Bolus ingestion of 25g protein

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* BMI between 18.5 and 30
* Recreationally active (\<3 times per week structured resistance exercise training)

Exclusion Criteria

* Any metabolic impairment
* Any cardiovascular impairment
* High blood pressure (\>140/90 mmHg)
* A personal history of epilepsy, seizures or schizophrenia
* Smoking
* Chronic (\>1 month) use of over the counter pharmaceuticals
* Chronic (\>2 months) use of amino acid or protein supplements
* Allergic to Quorn/mycoprotein or algae products
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Exeter

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Benjamin T Wall, PhD

Role: PRINCIPAL_INVESTIGATOR

Professor of Nutritional Physiology

Locations

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University of Exeter

Exeter, Devon, United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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200506/B/01

Identifier Type: -

Identifier Source: org_study_id

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