Effect of Low Intensity Exercise and Protein Intake on Skeletal Muscle Protein Synthesis in Elderly

NCT ID: NCT01640145

Last Updated: 2015-01-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-07-31

Study Completion Date

2014-10-31

Brief Summary

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Maintenance of skeletal muscle mass is crucial during lifespan to retain health and functional autonomy. Sarcopenia, being the loss of muscle mass during aging, is a well-known phenomenon in the elderly and a major challenge viewed from an individual, and a socioeconomic point of view. Nevertheless, several studies have proved muscle tissue to be markedly affected by physical activity and nutritional interventions even at old age. Recently, a study in young individuals showed that an acute bout of easily tolerated low intensity exercise can prolong the muscle building effects of a milk protein intake compared to a non-exercised situation. Therefore, the major aim of the present project is to evaluate, whether a low intensity exercise regime in conjunction with milk protein supplementation can induce positive adaptations on parameters related to muscle size and function in elderly.

The study focuses on the acute muscle protein synthesis response to low intensity exercise and protein supplementation measured with stable isotope tracer techniques. It is hypothesized that light muscle activity can augment and prolong the effects of protein feeding.

If a light resistance exercise protocol as investigated in the present project can prove beneficial, elderly, frail elderly, and individuals undergoing rehabilitation can challenge sarcopenia in a new and tolerable way.

Detailed Description

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Conditions

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Skeletal Muscle Protein Synthesis in Elderly Protein Kinetics Sarcopenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Carbohydrate

Group Type PLACEBO_COMPARATOR

Exercise

Intervention Type OTHER

Unilateral low intensity exercise

Protein continous boluses

Group Type ACTIVE_COMPARATOR

Protein

Intervention Type DIETARY_SUPPLEMENT

Whey protein intake

Exercise

Intervention Type OTHER

Unilateral low intensity exercise

Protein 2 boluses

Group Type ACTIVE_COMPARATOR

Protein

Intervention Type DIETARY_SUPPLEMENT

Whey protein intake

Exercise

Intervention Type OTHER

Unilateral low intensity exercise

Interventions

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Protein

Whey protein intake

Intervention Type DIETARY_SUPPLEMENT

Exercise

Unilateral low intensity exercise

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Male
* \>65 year old
* Healthy
* BMI \<28

Exclusion Criteria

* Smoker
* Type II diabetic
* Intake of medicine or supplements which will affect skeletal muscle protein synthesis
* Alcohol intake \>21 units/week.
* Frequent exercise or hard physical labor
Minimum Eligible Age

65 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Bispebjerg Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jakob Agergaard

MSc, PhD Student

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Institute of Sports Medicine Copenhagen

Copenhagen, Copenhagen, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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BBH98

Identifier Type: -

Identifier Source: org_study_id

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