Proteome Remodelling

NCT ID: NCT04136457

Last Updated: 2023-12-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

72 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-10-30

Study Completion Date

2023-11-28

Brief Summary

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The purpose of the project is to investigate the proteome signature dynamics and remodelling in human skeletal muscle induced by exercise training

Detailed Description

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Conditions

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Skeletal Muscle Physiology

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Endurance

Endurance training

Group Type EXPERIMENTAL

Endurance training

Intervention Type OTHER

Subjects perform a period of endurance training

Resistance

Resistance training

Group Type EXPERIMENTAL

Resistance training

Intervention Type OTHER

Subjects perform a period of resistance training

Sprint

Sprint training

Group Type EXPERIMENTAL

Sprint training

Intervention Type OTHER

Subjects perform a period of sprint training

Interventions

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Endurance training

Subjects perform a period of endurance training

Intervention Type OTHER

Resistance training

Subjects perform a period of resistance training

Intervention Type OTHER

Sprint training

Subjects perform a period of sprint training

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy men and women
* VO2max \> 55 mL/min/kgLM for men and \> 50 for women (only applicable for endurance and sprint training interventions)
* BMI \< 26

Exclusion Criteria

* Chronic disease deemed by the medical doctor to pose a risk or to affect study outcomes
* smoking
* Use of prescription medicine deemed by the medical to affect study outcomes
* Pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Morten Hostrup, PhD

OTHER

Sponsor Role lead

Responsible Party

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Morten Hostrup, PhD

Associate Professor

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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August Krogh Building

Copenhagen, , Denmark

Site Status

Countries

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Denmark

References

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Kissow J, Jacobsen KJ, Jessen S, Thomsen LB, Quesada JP, Bangsbo J, Deshmukh AS, Hostrup M. Global Proteomics Reveals Distinct Muscle Adaptations to Menstrual Cycle Phase-Based Sprint Interval Training in Endurance-Trained Females. Mol Cell Proteomics. 2025 Aug 14;24(10):101053. doi: 10.1016/j.mcpro.2025.101053. Online ahead of print.

Reference Type DERIVED
PMID: 40818533 (View on PubMed)

Other Identifiers

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MiDy

Identifier Type: -

Identifier Source: org_study_id