Fasting and Exercise-induced Changes in Human Skeletal Muscle

NCT ID: NCT03811717

Last Updated: 2019-05-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-01-14

Study Completion Date

2019-04-30

Brief Summary

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This study examines the impact of increasing energetic stress during an 8-hour fast on metabolic pathways in human skeletal muscle. Specifically, participants will undergo two 8-hour fasting sessions in a randomized crossover fashion, with the addition of low-intensity arm exercise in one of the sessions. Changes in metabolic pathways will be examined in resting (leg) muscle before, during, and after the fast.

Detailed Description

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Conditions

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Skeletal Muscle Energetics

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Investigators Outcome Assessors
Allocation concealment, assessor blinding

Study Groups

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FAST+EX - FAST

FAST+EX then FAST alone

Group Type EXPERIMENTAL

FAST+EX

Intervention Type OTHER

Participants will perform 2-hours of low-intensity arm exercise (8 x 15 min bouts of arm ergometer exercise separated by 10 min of rest) during an 8-hour fast.

FAST

Intervention Type OTHER

Participants will complete an 8-hour fast.

FAST - FAST+EX

FAST alone then FAST+EX

Group Type EXPERIMENTAL

FAST+EX

Intervention Type OTHER

Participants will perform 2-hours of low-intensity arm exercise (8 x 15 min bouts of arm ergometer exercise separated by 10 min of rest) during an 8-hour fast.

FAST

Intervention Type OTHER

Participants will complete an 8-hour fast.

Interventions

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FAST+EX

Participants will perform 2-hours of low-intensity arm exercise (8 x 15 min bouts of arm ergometer exercise separated by 10 min of rest) during an 8-hour fast.

Intervention Type OTHER

FAST

Participants will complete an 8-hour fast.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* recreationally active (no more than 3 hours of weekly physical activity)
* not currently involved in a systematic training program
* body mass index \< 30 kg/m2

Exclusion Criteria

* presence of cardiometabolic disease
* taking regular oral medication
* current smoker
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Waterloo

OTHER

Sponsor Role collaborator

Queen's University

OTHER

Sponsor Role lead

Responsible Party

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Brendon Gurd

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Brendon J. Gurd, PhD

Role: PRINCIPAL_INVESTIGATOR

Queen's University

Locations

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School of Kinesiology and Health Studies

Kingston, Ontario, Canada

Site Status

Countries

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Canada

Other Identifiers

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QMPL_HI-01-19

Identifier Type: -

Identifier Source: org_study_id

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