Erythrocytes and Skeletal-muscle Fatty Acids Are Positively Correlated After Caloric Restriction and Exercise

NCT ID: NCT02533479

Last Updated: 2015-08-26

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 11 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2010-01-31
• Study Completion Date: 2014-10-31

Brief Summary

The aim is compare and correlate skeletal muscle and erythrocytes fatty acids (FAs) profiles in adult healthy human after caloric restriction and acute exercise in order to validate erythrocyte FAs profile as marker of changes in muscle fatty acid composition.

Detailed Description

The study was performed with 11 healthy sportsmen participating in a caloric restriction trial for 1 month. The participants follow a caloric restriction, 30-40% respect to the usual diet of each participant, three alternate days weekly along 4 weeks. After the caloric restriction period the participants realized an exercise stress test. For each participant one blood sample and muscular biopsy were obtained after acute exercise and caloric restriction intervention. All the participants were informed of the purpose and demands of the study before giving their written consent to participate. The study protocol was in accordance with the Declaration of Helsinki for research on human participants and was approved by the local Ethics Committee of the Consell Català de l'Esport.

Conditions

Dietary Modification

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Caloric restriction

three alternate days weekly along 4 weeks.

Group Type: EXPERIMENTAL

Caloric restriction

Intervention Type: OTHER

three alternate days weekly along 4 weeks.

Interventions

Caloric restriction

three alternate days weekly along 4 weeks.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• age (18-50 years old),
• sex (male),
• equilibrate diet and physical activity of 3 days weekly.

Exclusion Criteria

• sex (female),
• smokers.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Centre d'Alt Rendiment

OTHER

Sponsor Role: lead

Responsible Party

FRANCISCO DROBNIC, MD, PhD

PhD in Medicine

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Franchek Drobnic, Ph D

Role: STUDY_CHAIR

Centre d'Alt Rendiment, Sant Cugat

Locations

Centre D'Alt Rendinemt, Sant Cugat

Barcelona, , Spain

Countries

Spain

References

Capo X, Martorell M, Sureda A, Tur JA, Pons A. Effects of docosahexaenoic supplementation and in vitro vitamin C on the oxidative and inflammatory neutrophil response to activation. Oxid Med Cell Longev. 2015;2015:187849. doi: 10.1155/2015/187849. Epub 2015 Apr 19.

Reference Type: BACKGROUND

PMID: 25960826 (View on PubMed)

Pons V, Riera J, Capo X, Martorell M, Sureda A, Tur JA, Drobnic F, Pons A. Calorie restriction regime enhances physical performance of trained athletes. J Int Soc Sports Nutr. 2018 Mar 9;15:12. doi: 10.1186/s12970-018-0214-2. eCollection 2018.

Reference Type: DERIVED

PMID: 29556158 (View on PubMed)

Other Identifiers

CAR-1

Identifier Type: -

Identifier Source: org_study_id