Accelerating Post-exercise Muscle Glycogen Resynthesis in Humans: Impact of Combined Nutrient Intake and Intermittent Pneumatic Compression or Heat Therapy
NCT ID: NCT04371237
Last Updated: 2021-03-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
26 participants
INTERVENTIONAL
2018-09-19
2019-12-21
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Intermittent pneumatic compression
IPC sleeve device on leg
Compression sleeve
From foot to hip/groin on both legs with only 1 leg connected to pneumatic pump for 1 hour
Glycogen-depleting exercise session
Prolonged intermittent high intensity running (LIST protocol)
Nutrient Intake (beverage)
Post-exercise, all participants will receive a beverage containing 1.0 g/kg carbohydrate and 0.3 g/kg protein from the mixture of Gatorade Recover Protein Shake and Gatorade Thirst Quencher
Skeletal muscle biopsy
Vastus lateralis muscle in the lower thigh will be obtained by the percutaneous needle technique
Heat therapy
Custom water-circulating garment on leg
Heat therapy
Custom leg garment with one leg heated by circulating hot water approx 40 degrees C, the other leg approx 32 degrees C (thermoneutral) for 1 hour
Glycogen-depleting exercise session
Prolonged intermittent high intensity running (LIST protocol)
Nutrient Intake (beverage)
Post-exercise, all participants will receive a beverage containing 1.0 g/kg carbohydrate and 0.3 g/kg protein from the mixture of Gatorade Recover Protein Shake and Gatorade Thirst Quencher
Skeletal muscle biopsy
Vastus lateralis muscle in the lower thigh will be obtained by the percutaneous needle technique
Interventions
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Compression sleeve
From foot to hip/groin on both legs with only 1 leg connected to pneumatic pump for 1 hour
Heat therapy
Custom leg garment with one leg heated by circulating hot water approx 40 degrees C, the other leg approx 32 degrees C (thermoneutral) for 1 hour
Glycogen-depleting exercise session
Prolonged intermittent high intensity running (LIST protocol)
Nutrient Intake (beverage)
Post-exercise, all participants will receive a beverage containing 1.0 g/kg carbohydrate and 0.3 g/kg protein from the mixture of Gatorade Recover Protein Shake and Gatorade Thirst Quencher
Skeletal muscle biopsy
Vastus lateralis muscle in the lower thigh will be obtained by the percutaneous needle technique
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. 18-35 years of age
3. Currently performing cardiovascular or intermittent exercise at a moderate to high intensity at least 5 days per week for 60 minutes or longer per day.
4. Understanding of the procedures to be undertaken as part of the study
5. Willingness to participate in exercise testing and follow instructions provided by the experimenter
6. Informed, voluntary, written consent to participate in the study
Exclusion Criteria
2. Obesity (BMI \> 30 kg/m2)
3. Hypertension (resting SBP \> 140/90 mmHg)
4. Smoking
5. Pregnant, planning to become pregnant, or lactating
6. Supplements containing antioxidants including vitamin C and E and N-acetyl cysteine
7. Any medication
8. Lactose intolerance
9. Participation in another study within the previous 30 days or in a PepsiCo funded study within the past 6 months.
18 Years
35 Years
ALL
Yes
Sponsors
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PepsiCo Global R&D
INDUSTRY
Responsible Party
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Principal Investigators
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Bruno Roseguini, PhD
Role: PRINCIPAL_INVESTIGATOR
Purdue University
Locations
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Purdue University, Department of Health & Kinesiology
West Lafayette, Indiana, United States
Countries
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Other Identifiers
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PEP-1723
Identifier Type: -
Identifier Source: org_study_id
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