Beta-lactoglobulin, Immobilisation and Muscle Protein Synthesis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-04-01

Study Completion Date

2024-08-01

Brief Summary

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The objectives of this study are to:

1. Establish whether combined β-lactoglobulin supplementation and resistance training for 1 week prior to 5 days of limb immobilisation will attenuate the decrease in integrated free-living rates of MPS during short-term muscle disuse.
2. Establish whether combined β-lactoglobulin supplementation and resistance training for 1 week prior to limb immobilisation will attenuate the decrease in muscle mass and strength during short-term muscle disuse.

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Detailed Description

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The objectives of this study are to:

1. Establish whether combined β-lactoglobulin supplementation and resistance training for 1 week prior to 5 days of limb immobilisation will attenuate the decrease in integrated free-living rates of MPS during short-term muscle disuse.
2. Establish whether combined β-lactoglobulin supplementation and resistance training for 1 week prior to limb immobilisation will attenuate the decrease in muscle mass and strength during short-term muscle disuse.

Hypotheses

1. Combining β-lactoglobulin and resistance training for 1 wk prior to 5 d of limb immobilisation will attenuate the decrease in integrated muscle protein synthesis, muscle fibre CSA, quadriceps muscle strength, and leg lean mass during muscle disuse.
2. Combining β-lactoglobulin and resistance training for 1 wk prior to 5 d of limb immobilisation will attenuate the decrease in muscle fibre CSA, quadriceps muscle strength, and leg lean mass during muscle disuse.

Conditions

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Muscle Atrophy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

This study is a double-blind, 2-arm, randomised placebo-controlled trial

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Double blinded to supplement (beta-lactoglobulin or carbohydrate)

Study Groups

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Beta-lactoglobulin

Daily supplementation over 12 day period. A nutritional supplement.

Group Type EXPERIMENTAL

Beta-lactoglobulin

Intervention Type DIETARY_SUPPLEMENT

Beta-lactoglobulin (BLG) will be administered thrice daily during a 7 day period of prehabilitation and 5 day period of immobilisation when the leg is placed in a brace.

Carbohydrate

Daily supplementation over 12 day period. Energy matched control.

Group Type PLACEBO_COMPARATOR

Carbohydrate

Intervention Type DIETARY_SUPPLEMENT

Carbohydrate (dextrose monohydrate) will be administered thrice daily during a 7 day period of prehabilitation and 5 day period of immobilisation when the leg is placed in a brace.

Interventions

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Beta-lactoglobulin

Beta-lactoglobulin (BLG) will be administered thrice daily during a 7 day period of prehabilitation and 5 day period of immobilisation when the leg is placed in a brace.

Intervention Type DIETARY_SUPPLEMENT

Carbohydrate

Carbohydrate (dextrose monohydrate) will be administered thrice daily during a 7 day period of prehabilitation and 5 day period of immobilisation when the leg is placed in a brace.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Male and female
* Aged 18-45 years
* Healthy
* Physically active (≥150-300 minutes of moderate-intensity aerobic physical activity per week OR 75-150 minutes of vigorous-intensity aerobic physical activity per week)
* Eumenorrheic and not taking any hormonal birth control (females)

Exclusion Criteria

* Dairy allergy or intolerance
* Lower limb injury or surgery in the last 6 months,
* Lower limb osteoarthritis or other musculoskeletal disorder
* A musculoskeletal or blood blotting disorder
* An allergy to local anaesthetic
* Currently pregnant
* Current use of blood thinning medications
* Volunteers that take part in structured resistance exercise training
* Taking supplements considered to be anabolic to skeletal muscle (protein supplements, creatine, or omega-3 supplements)
* Consuming more than 1.2 grams of protein per kilogram of body mass per day in their habitual diet.
* Volunteers involved in other studies at the time of enrolment
* Volunteers who have taken part in a tracer study in the past 18 months
* If without an understanding of verbal or written English
* Volunteers with a history of eating disorders

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes