NMES During the Day and Prior to Sleep

NCT ID: NCT02253329

Last Updated: 2015-05-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-01-31

Study Completion Date

2015-05-31

Brief Summary

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In the present study, the effect of a bolus of intrinsically labeled milk directly after one-legged NMES (Neuromuscular Electrical Stimulation) will be studied under two conditions: during the day and prior to sleep

Detailed Description

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In the present study, the effect of a bolus of intrinsically labeled milk directly after an hour of one-legged NMES (Neuromuscular Electrical Stimulation) will be studied under two conditions: during the day and immediately prior to sleep

Conditions

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Sarcopenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Treatment during the day

Neuromuscular electrical stimulation after a protein bolus, performed during the day

Group Type ACTIVE_COMPARATOR

Dietary protein plus NMES during the day

Intervention Type PROCEDURE

Neuromuscular electrical stimulation after a protein bolus, performed during the day

Treatment prior to sleep

Protein ingestion directly after one-legged NMES, directly prior to sleep

Group Type ACTIVE_COMPARATOR

Dietary protein plus NMES prior to sleep

Intervention Type PROCEDURE

Neuromuscular electrical stimulation after a protein bolus, performed prior to sleep

Interventions

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Dietary protein plus NMES during the day

Neuromuscular electrical stimulation after a protein bolus, performed during the day

Intervention Type PROCEDURE

Dietary protein plus NMES prior to sleep

Neuromuscular electrical stimulation after a protein bolus, performed prior to sleep

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Age 65-85 years
* Male
* 18.5 ≤ BMI ≤ 30.0

Exclusion Criteria

* Type II diabetes
* All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthrosis, arthritis, spasticity/rigidity, all neurological disorders, paralysis, hip/knee surgery).
* Use of anticoagulants, blood diseases, allergy for lidocaine
* Use of NSAIDs (non-steroidal anti-inflammatory drugs) and acetylsalicylic acid
* Patients suffering from PKU (Phenylketonuria)
* Presence of implantable cardioverter defibrillator and/or pacemaker
* Performed regular resistance type exercise in the past 6 months
* Use of any tools to assist during walking (cane/ crutches/ walker)
* (Partial) foot/ leg amputation
Minimum Eligible Age

65 Years

Maximum Eligible Age

85 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Maastricht University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Luc JC van Loon, PhD

Role: PRINCIPAL_INVESTIGATOR

Maastricht University Medical Center

Locations

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Maastricht University Medical Centre +

Maastricht, , Netherlands

Site Status

Countries

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Netherlands

Other Identifiers

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MEC 14-3-042

Identifier Type: -

Identifier Source: org_study_id

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