Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2015-10-31
2016-04-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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Intermittent feeding
Intermittent feeding pattern throughout the bedrest period, with 4 boluses per day
Intermittent feeding pattern
Intermittent feeding
Continuous feeding
Continuous feeding pattern throughout the bedrest period, with 4 boluses per day, without breaks in food supply.
Continuous feeding pattern
Continuous feeding
Interventions
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Intermittent feeding pattern
Intermittent feeding
Continuous feeding pattern
Continuous feeding
Eligibility Criteria
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Inclusion Criteria
* Recreationally active
Exclusion Criteria
* Performing progressive resistance training in 6 months prior to study
* Back/knee/leg problems
* Hypertension
* Use of certain anticoagulants
* All co morbidities interacting with mobility and muscle metabolism of the lower limbs
* Blood donation in past 3 months
18 Years
35 Years
MALE
Yes
Sponsors
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Maastricht University Medical Center
OTHER
Responsible Party
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Principal Investigators
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Luc van Loon
Role: PRINCIPAL_INVESTIGATOR
Maastricht University Medical Centre+
Locations
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Maastricht University Medical Center+
Maastricht, Limburg, Netherlands
Countries
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References
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Gonzalez JT, Dirks ML, Holwerda AM, Kouw IWK, van Loon LJC. Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest. Eur J Appl Physiol. 2020 Sep;120(9):2083-2094. doi: 10.1007/s00421-020-04431-4. Epub 2020 Jul 10.
Dirks ML, Miotto PM, Goossens GH, Senden JM, Petrick HL, van Kranenburg J, van Loon LJC, Holloway GP. Short-term bed rest-induced insulin resistance cannot be explained by increased mitochondrial H2 O2 emission. J Physiol. 2020 Jan;598(1):123-137. doi: 10.1113/JP278920. Epub 2019 Dec 26.
Dirks ML, Smeets JSJ, Holwerda AM, Kouw IWK, Marzuca-Nassr GN, Gijsen AP, Holloway GP, Verdijk LB, van Loon LJC. Dietary feeding pattern does not modulate the loss of muscle mass or the decline in metabolic health during short-term bed rest. Am J Physiol Endocrinol Metab. 2019 Mar 1;316(3):E536-E545. doi: 10.1152/ajpendo.00378.2018. Epub 2019 Jan 15.
Other Identifiers
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MEC 15-3-035
Identifier Type: -
Identifier Source: org_study_id
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