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Two-day Bed Rest, Insulin Sensitivity and Muscle Protein Synthesis

NCT ID: NCT03877822

Last Updated: 2021-11-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2021-09-01

Study Completion Date

2021-09-01

Brief Summary

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The impact of two days bed rest versus two days of habitual activity on insulin sensitivity and cumulative muscle protein synthesis will be investigated in healthy young males

Detailed Description

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To study the mechanisms underlying inactivity-induced muscle atrophy, the impact of two days bed rest versus two days of habitual activity on insulin sensitivity and cumulative muscle protein synthesis will be investigated in healthy young males

Conditions

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Healthy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Participants will firstly undergo 2 days of habitual physical activity, followed by 2 days of bed rest
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Habitual activity and 2 days bed rest

Participants will undergo 2 days of habitual activity and 2 days bed rest

Group Type EXPERIMENTAL

Habitual activity

Intervention Type BEHAVIORAL

Two days of habitual physical activity, under normal free-living conditions

Bed rest

Intervention Type BEHAVIORAL

Two days of bed rest, to induce whole-body physical inactivity

Interventions

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Habitual activity

Two days of habitual physical activity, under normal free-living conditions

Intervention Type BEHAVIORAL

Bed rest

Two days of bed rest, to induce whole-body physical inactivity

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Male
* Aged 18-40

Exclusion Criteria

* Smoker
* Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes)
* Any diagnosed cardiovascular disease (e.g. deep vein thrombosis or hypertension)
* Chronic use of any prescribed or over the counter pharmaceuticals (that may modulate muscle protein metabolism).
* A personal or family history of thrombosis, epilepsy, seizures or schizophrenia.
* Any known disorders in muscle metabolism
* Regular use of nutritional supplements (i.e. ingestion more than twice per week during the last month)
* Metallic implants (including heart pacemaker, cochlear implants, medication pumps, surgical clips, plates or screws).
* Allergy to lidocaine
* Recent (within the last 6 months) or current musculoskeletal injury (e.g. leg fracture)
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Exeter

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Marlou L Dirks, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Exeter

Other Identifiers

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190206/B/05

Identifier Type: -

Identifier Source: org_study_id