Exercise and Nutrition Interventions in Age-related Sarcopenia
NCT ID: NCT02912130
Last Updated: 2025-09-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
110 participants
INTERVENTIONAL
2016-09-30
2023-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
FACTORIAL
PREVENTION
NONE
Study Groups
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Control
No Intervention
No interventions assigned to this group
Exercise
1. Aerobic Exercise i.e. 30-60 minutes per week of moderate intensity exercise
2. Resistance Exercise i.e. 60 minutes per week of progressive resistance training
Aerobic Exercise
30-60 minutes per week of moderate intensity exercise
Resistance Exercise
60 minutes per week of progressive resistance training
Exercise+Nutrition
1. Aerobic Exercise i.e. 30-60 minutes per week of moderate intensity exercise
2. Dietary Supplement i.e. Protein Supplementation 1.2-1.5g/kg/body weight per day
Protein Supplementation
1.2-1.5g/kg/body weight per day
Aerobic Exercise
30-60 minutes per week of moderate intensity exercise
Resistance Exercise
60 minutes per week of progressive resistance training
Nutrition
Dietary Supplement: Protein Supplementation i.e. 1.2-1.5g/kg/body weight per day
Protein Supplementation
1.2-1.5g/kg/body weight per day
Interventions
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Protein Supplementation
1.2-1.5g/kg/body weight per day
Aerobic Exercise
30-60 minutes per week of moderate intensity exercise
Resistance Exercise
60 minutes per week of progressive resistance training
Eligibility Criteria
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Inclusion Criteria
* 60 - 90 years of age
* Resident in North West, England, UK
* BMI 18.5-30 kg/m
* Can speak and understand English
* Willing to consent and follow the study procedures
Exclusion Criteria
* Self-reported lactose intolerance
* Uncontrolled diabetes (HbA1C \>10)
* Uncontrolled Hypertension (160/100) and uncontrolled hypotension (\<100 systolic)
* Treatment with Beta Blockers, Calcium Channel Blockers, Digitalis, Bronchodilator,
* Diuretics, Vasodilators
* Current hormone therapy such as insulin, testosterone or hormone replacement therapy
* History of falls/osteoporosis
* Major psychological/mental illness
* Medical conditions that precluded safe participation in an exercise program
* Other major systemic diseases: Liver and kidney diseases, Advanced gastrointestinal disorders, Cardiovascular Diseases, Advanced chronic obstructive pulmonary disease, Advanced Rheumatoid Arthritis, Cancer
60 Years
90 Years
ALL
Yes
Sponsors
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Liverpool Hope University
OTHER
Responsible Party
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Omid Khaiyat, MD, PhD
Dr
Principal Investigators
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Dr Omid Alizadehkhaiyat, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Liverpool Hope University
Locations
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Liverpool Hope University
Liverpool, Merseyside, United Kingdom
Countries
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References
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Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M; European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010 Jul;39(4):412-23. doi: 10.1093/ageing/afq034. Epub 2010 Apr 13.
Witard OC, Wardle SL, Macnaughton LS, Hodgson AB, Tipton KD. Protein Considerations for Optimising Skeletal Muscle Mass in Healthy Young and Older Adults. Nutrients. 2016 Mar 23;8(4):181. doi: 10.3390/nu8040181.
Lourenco RA, Perez-Zepeda M, Gutierrez-Robledo L, Garcia-Garcia FJ, Rodriguez Manas L. Performance of the European Working Group on Sarcopenia in Older People algorithm in screening older adults for muscle mass assessment. Age Ageing. 2015 Mar;44(2):334-8. doi: 10.1093/ageing/afu192. Epub 2014 Dec 23.
Yu SC, Khow KS, Jadczak AD, Visvanathan R. Clinical Screening Tools for Sarcopenia and Its Management. Curr Gerontol Geriatr Res. 2016;2016:5978523. doi: 10.1155/2016/5978523. Epub 2016 Feb 4.
Churchward-Venne TA, Holwerda AM, Phillips SM, van Loon LJ. What is the Optimal Amount of Protein to Support Post-Exercise Skeletal Muscle Reconditioning in the Older Adult? Sports Med. 2016 Sep;46(9):1205-12. doi: 10.1007/s40279-016-0504-2.
Kraschnewski JL, Sciamanna CN, Poger JM, Rovniak LS, Lehman EB, Cooper AB, Ballentine NH, Ciccolo JT. Is strength training associated with mortality benefits? A 15year cohort study of US older adults. Prev Med. 2016 Jun;87:121-127. doi: 10.1016/j.ypmed.2016.02.038. Epub 2016 Feb 24.
Witard OC, McGlory C, Hamilton DL, Phillips SM. Growing older with health and vitality: a nexus of physical activity, exercise and nutrition. Biogerontology. 2016 Jun;17(3):529-46. doi: 10.1007/s10522-016-9637-9. Epub 2016 Feb 15.
Chang SF, Lin PL. Systematic Literature Review and Meta-Analysis of the Association of Sarcopenia With Mortality. Worldviews Evid Based Nurs. 2016 Apr;13(2):153-62. doi: 10.1111/wvn.12147. Epub 2016 Feb 4.
Csapo R, Alegre LM. Effects of resistance training with moderate vs heavy loads on muscle mass and strength in the elderly: A meta-analysis. Scand J Med Sci Sports. 2016 Sep;26(9):995-1006. doi: 10.1111/sms.12536. Epub 2015 Aug 24.
Xu ZR, Tan ZJ, Zhang Q, Gui QF, Yang YM. Clinical effectiveness of protein and amino acid supplementation on building muscle mass in elderly people: a meta-analysis. PLoS One. 2014 Sep 30;9(9):e109141. doi: 10.1371/journal.pone.0109141. eCollection 2014.
Komar B, Schwingshackl L, Hoffmann G. Effects of leucine-rich protein supplements on anthropometric parameter and muscle strength in the elderly: a systematic review and meta-analysis. J Nutr Health Aging. 2015 Apr;19(4):437-46. doi: 10.1007/s12603-014-0559-4.
Ko SU, Hausdorff JM, Ferrucci L. Age-associated differences in the gait pattern changes of older adults during fast-speed and fatigue conditions: results from the Baltimore longitudinal study of ageing. Age Ageing. 2010 Nov;39(6):688-94. doi: 10.1093/ageing/afq113. Epub 2010 Sep 10.
Kirk B, Mooney K, Vogrin S, Jackson M, Duque G, Khaiyat O, Amirabdollahian F. Leucine-enriched whey protein supplementation, resistance-based exercise, and cardiometabolic health in older adults: a randomized controlled trial. J Cachexia Sarcopenia Muscle. 2021 Dec;12(6):2022-2033. doi: 10.1002/jcsm.12805. Epub 2021 Sep 14.
Kirk B, Mooney K, Amirabdollahian F, Khaiyat O. Exercise and Dietary-Protein as a Countermeasure to Skeletal Muscle Weakness: Liverpool Hope University - Sarcopenia Aging Trial (LHU-SAT). Front Physiol. 2019 Apr 25;10:445. doi: 10.3389/fphys.2019.00445. eCollection 2019.
Other Identifiers
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LiverpoolHU
Identifier Type: -
Identifier Source: org_study_id
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