Prevalence and Effect of Lifestyle Modification on Clinical Outcomes and Cost-effectiveness Ratio for Sarcopenia

NCT ID: NCT02873676

Last Updated: 2020-06-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-03-31

Study Completion Date

2020-12-31

Brief Summary

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The purposes of this study were to investigate the prevalence and risk factors for sarcopenia in Chinese adults and elderly, and evaluate the effect of Lifestyle Modification Project (LMP) on Clinical Outcomes, Quality of Life and Cost-effectiveness Ratio.

Detailed Description

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Conditions

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Sarcopenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

SINGLE

Participants

Study Groups

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nutritional intervention

This group received multi-dimensional intensive nutritional intervention for 3 month, which included whey (30g/d,plus three times every week ),vitamin D (1000IU) and omega-3 fatty acid (DHA 1200mg and EPA 800mg).

Group Type EXPERIMENTAL

nutritional intervention

Intervention Type BEHAVIORAL

The intervention is made up of nutrition supplements and dietary pattern modification, which includes whey 30g/d(plus three times every week),vitamin D 1000IU, omega-3 fatty acid (DHA1200mg and EPA 800mg)

resistance training program

This group received resistance training program which is made up warm-up exercise, muscle strength training and relaxing.

Group Type EXPERIMENTAL

resistance training program

Intervention Type BEHAVIORAL

The training program involve warm-up exercise, muscle strength training and relaxing

lifestyle modification project

This group receive multi-dimensional intensive nutritional intervention and resistance training program.

Group Type EXPERIMENTAL

lifestyle modification project

Intervention Type BEHAVIORAL

Lifestyle modification project is made up of multi-dimensional intensive nutritional intervention and resistance training

control

This group receive nutritional consulting,which involve dietary pattern modification and protein intake standardization.

Group Type PLACEBO_COMPARATOR

control

Intervention Type BEHAVIORAL

The intervention involve dietary pattern modification and protein intake standardization

Interventions

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nutritional intervention

The intervention is made up of nutrition supplements and dietary pattern modification, which includes whey 30g/d(plus three times every week),vitamin D 1000IU, omega-3 fatty acid (DHA1200mg and EPA 800mg)

Intervention Type BEHAVIORAL

resistance training program

The training program involve warm-up exercise, muscle strength training and relaxing

Intervention Type BEHAVIORAL

lifestyle modification project

Lifestyle modification project is made up of multi-dimensional intensive nutritional intervention and resistance training

Intervention Type BEHAVIORAL

control

The intervention involve dietary pattern modification and protein intake standardization

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* age\>=18 year The participants must have basic cognitive function and communication Must be able to provide a written informed consent

Exclusion Criteria

* age\<18 year Concurrent severe cardiac disease, unstable diabetes mellitus,uncontrolled chronic disease,liver and renal failer, which may significantly interfere with study compliance.

Participants received any drugs or supplements known to influence effcet size,such as protein powder, calcium, or vitamin D before the 3 months preceding the study. Participants with electronic or mental device
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Peking Union Medical College Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kang Yu

Role: STUDY_CHAIR

Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College

Locations

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Peking Union Medical College Hospital

Beijing, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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Kang Yu

Role: CONTACT

+86 10 69155550

Facility Contacts

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Kang Yu

Role: primary

+86 13801130457

References

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Li CW, Li Q, Liu Y, Zhang Y, Wang ZK, Xing Y, Niu YS, Pang Y, Yu K. Sarcopenic obesity exacerbates gastric cancer prognosis via increased intermuscular and visceral fat accumulation. Eur J Med Res. 2025 Oct 22;30(1):1012. doi: 10.1186/s40001-025-03251-6.

Reference Type DERIVED
PMID: 41126316 (View on PubMed)

Li Z, Cui M, Yu K, Zhang XW, Li CW, Nie XD, Wang F. Effects of nutrition supplementation and physical exercise on muscle mass, muscle strength and fat mass among sarcopenic elderly: a randomized controlled trial. Appl Physiol Nutr Metab. 2021 May;46(5):494-500. doi: 10.1139/apnm-2020-0643. Epub 2020 Nov 20.

Reference Type DERIVED
PMID: 33216623 (View on PubMed)

Li CW, Yu K, Shyh-Chang N, Li GX, Jiang LJ, Yu SL, Xu LY, Liu RJ, Guo ZJ, Xie HY, Li RR, Ying J, Li K, Li DJ. Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention. J Cachexia Sarcopenia Muscle. 2019 Jun;10(3):586-600. doi: 10.1002/jcsm.12417. Epub 2019 Apr 10.

Reference Type DERIVED
PMID: 30969486 (View on PubMed)

Other Identifiers

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PUMCH344801

Identifier Type: -

Identifier Source: org_study_id

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