Amino Acid Balance During Physical Inactivity

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

22 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-01-31

Study Completion Date

2018-09-30

Brief Summary

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The aim is to assess the impact of physical inactivity on muscle amino acid balance and forearm glucose uptake. In addition, we will evaluate how high-fat overfeeding will modulate muscle amino acid balance and forearm glucose uptake.

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Detailed Description

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The aim is to assess the impact of forearm cast immobilization on muscle amino acid balance and forearm glucose uptake. In addition, we will evaluate how high-fat overfeeding during immobilization will modulate muscle amino acid balance and forearm glucose uptake.

Conditions

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Assessing Muscle Amino Acid Balance

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Energy-balanced diet

Forearm immobilization whilst consuming an energy-balanced diet

Group Type PLACEBO_COMPARATOR

Forearm immobilization

Intervention Type OTHER

High-fat overfeeding

Forearm immobilization whilst consuming a high-fat diet, 50% energy excess

Group Type EXPERIMENTAL

High-fat overfeeding

Intervention Type OTHER

Forearm immobilization

Intervention Type OTHER

Interventions

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High-fat overfeeding

Intervention Type OTHER

Forearm immobilization

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* BMI between 18 and 30

Exclusion Criteria

* Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes).
* Any diagnosed cardiovascular disease or hypertension.
* Elevated blood pressure at the time of screening. (An average systolic blood pressure reading of ≥140 mmHg over two or more measurements and an average diastolic blood pressure of ≥90 mmHg over two or more measurements.)
* Chronic use of any prescribed or over the counter pharmaceuticals.
* Regular use of nutritional supplements (e.g. creatine, protein supplementation)
* Metallic implants (including heart pacemaker, cochlear implants, medication pumps, surgical clips, plates or screws).
* A personal or family history of thrombosis, epilepsy, seizures or schizophrenia.
* Any previous motor disorders.

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes