Resistant Starch and Whey Protein on Energy Metabolism

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

32 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-08-31

Study Completion Date

2018-08-31

Brief Summary

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Recent evidence shows that dietary supplementation with resistant starch (RS) increases fat catabolism and resting energy expenditure and decreases plasma insulin and glucose responses as well as the gut-derived hormone, glucose-dependent insulinotropic polypeptide (GIP). Consumption of whey protein has also been shown to increase energy expenditure and favorably affect gut hormones. Thus, investigators tested consumption of both RS and whey protein on energy expenditure and gut hormones in lean and obese women and men.

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Detailed Description

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Consumed separately, resistant starch (RS) and whey protein (WP) favorably affect energy metabolism and gut hormones, as well as suppress feelings of hunger. These findings are important because release of certain gut hormones (i.e., GIP) is associated with a lower resting energy expenditure (REE) in healthy humans. Interestingly, a recent study showed that ingestion of RS reduces postprandial GIP and increases postprandial REE and fat utilization in healthy men and therefore may be an effective strategy in weight management. Thus, there is a need to replicate these findings in a healthy cohort of lean and obese women and men.

The purpose of this study was to examine the effects of RS on the number of calories burned after eating a meal, as well as specific hormones that are released from the stomach and intestines following meal ingestion in healthy lean and obese women and men. Investigators used a single ingestion of a meal supplemented with or without the resistant starch and whey protein.

Conditions

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Weight Loss

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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waxy maize starch

pancake test meal - waxy maize starch

Group Type ACTIVE_COMPARATOR

waxy maize starch

Intervention Type OTHER

pancake test meal with waxy maize starch only

waxy maize starch and whey protein

pancake test meal - waxy maize starch and whey protein

Group Type ACTIVE_COMPARATOR

waxy maize starch

Intervention Type OTHER

pancake test meal with waxy maize starch only

waxy maize starch and Whey Protein

Intervention Type OTHER

pancake test meal with waxy maize starch and whey protein

resistant starch

pancake test meal - resistant starch

Group Type ACTIVE_COMPARATOR

Resistant Starch

Intervention Type OTHER

pancake test meal with resistant starch only

resistant starch and whey protein

pancake test meal - resistant starch and whey protein

Group Type ACTIVE_COMPARATOR

Resistant Starch

Intervention Type OTHER

pancake test meal with resistant starch only

resistant starch and whey protein

Intervention Type OTHER

pancake test meal with resistant starch and whey protein

Interventions

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waxy maize starch

pancake test meal with waxy maize starch only

Intervention Type OTHER

waxy maize starch and Whey Protein

pancake test meal with waxy maize starch and whey protein

Intervention Type OTHER

Resistant Starch

pancake test meal with resistant starch only

Intervention Type OTHER

resistant starch and whey protein

pancake test meal with resistant starch and whey protein

Intervention Type OTHER

Other Intervention Names

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WMS WMS-WP RS RS-WP

Eligibility Criteria

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Inclusion Criteria

* overweight or lean but otherwise healthy

Exclusion Criteria

* Participants will be excluded if they smoke; have experienced excessive weight loss/gain of \> ±2kg in the previous 2 months; are currently taking medications for cardiovascular or metabolic disease.

Minimum Eligible Age

30 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes