The Effect of Menstrual Cycle Phase and Protein Dose on Muscle Protein Synthesis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-01-16

Study Completion Date

2023-03-31

Brief Summary

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Adaptation to resistance exercise requires maximal rates of muscle protein synthesis, which can be achieved with post-exercise ingestion of \~20g of protein. These recommendations are based on studies in males and responses in females may vary.

Muscle recovery is related to the ability to build new muscle protein from amino acids (muscle protein synthesis). This response is thought to be impacted in females by hormones that fluctuate across different phases of the menstrual cycle. However, the effect of menstrual cycle phase on muscle protein synthesis is not known.

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Detailed Description

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Conditions

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Muscle Protein Synthesis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Protein dose 1 and early

Group Type EXPERIMENTAL

Dose of protein

Intervention Type DIETARY_SUPPLEMENT

One of three protein doses provided

Menstrual cycle phase

Intervention Type OTHER

Different phase of the menstrual cycle

Protein dose 1 and late

Group Type EXPERIMENTAL

Dose of protein

Intervention Type DIETARY_SUPPLEMENT

One of three protein doses provided

Menstrual cycle phase

Intervention Type OTHER

Different phase of the menstrual cycle

Protein dose 2 and early

Group Type EXPERIMENTAL

Dose of protein

Intervention Type DIETARY_SUPPLEMENT

One of three protein doses provided

Menstrual cycle phase

Intervention Type OTHER

Different phase of the menstrual cycle

Protein dose 2 and late

Group Type EXPERIMENTAL

Dose of protein

Intervention Type DIETARY_SUPPLEMENT

One of three protein doses provided

Menstrual cycle phase

Intervention Type OTHER

Different phase of the menstrual cycle

Protein dose 3 and early

Group Type EXPERIMENTAL

Dose of protein

Intervention Type DIETARY_SUPPLEMENT

One of three protein doses provided

Menstrual cycle phase

Intervention Type OTHER

Different phase of the menstrual cycle

Protein dose 3 and late

Group Type EXPERIMENTAL

Dose of protein

Intervention Type DIETARY_SUPPLEMENT

One of three protein doses provided

Menstrual cycle phase

Intervention Type OTHER

Different phase of the menstrual cycle

Interventions

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Dose of protein

One of three protein doses provided

Intervention Type DIETARY_SUPPLEMENT

Menstrual cycle phase

Different phase of the menstrual cycle

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* BMI between 18 and 30
* Recreationally active
* Regular menstrual cycle

Exclusion Criteria

* Smoking
* Metabolic disease
* Any motor disorder
* Use of over-the-counter pharmaceuticals, during the study.
* Pomegranate, milk or lidocaine allergy
* Taken contraceptives in the past 3 months
* Irregular menstrual cycle (less than 9 cycles per year and a length not between 21-35 days)
* Post-menopausal women
* Pregnancy and lactation

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes