Effects of Whey Protein and Collagen Supplementation

NCT ID: NCT04213586

Last Updated: 2020-01-30

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 22 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-09-01
• Study Completion Date: 2019-12-05

Brief Summary

The present project aims to investigate the effects of high-quality protein (whey protein) vs. low-quality protein (collagen) on muscle mass and function (e.g., strength and power) during a 10-wk resistance training program in young adults. It will be tested the hypothesis that leucine-matched collagen should promote similar gains on muscle function and mass compared to whey protein supplementation.

Detailed Description

The purpose of this study will be to investigate the effects of whey protein vs. leucine-matched collagen supplementation on muscle mass and function after a 10-wk resistance training program. Initially, all participants will be submitted for a 2-wk familiarization period, and then randomized into two groups (N = 11 / group): whey protein group and leucine-matched collagen group. The following variables will be assessed from pre-to post-training: anthropometric, muscle thickness from vastus lateralis and biceps brachii muscles using ultrasound, training load, mean power and peak torque for unilateral arm flexion exercise using a isokinetic dynamometer, countermovement vertical jump, nutritional intake, and testosterone-to-cortisol ratio . Shapiro-Wilk and Levine tests will be used to test the normality and homogeneity of the measurements, respectively. Two-way ANOVA (group x time) tests for repeated measures will be performed to assess changes over time and between groups for all dependent variables. Violation of sphericity will adjust using Greenhouse- Geyser correction. The Bonferroni post-hoc test will detect specific differences between groups. When appropriate, the percentage of change (∆%) will be reported according to the following equation: ∆% = [(pre-average post average) / pre-average mean] × 100. Values will be express as mean ± standard deviation. O significance level α will be 0.05.

Conditions

Exercise; Nutrition Therapy; Resistance Training; Muscle Strength; Hypertrophy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: DOUBLE

Study Groups

Whey Protein

Each participant will be supplemented with whey protein (7 d/wk) during 10 weeks.

Group Type: EXPERIMENTAL

Whey protein supplementation

Intervention Type: DIETARY_SUPPLEMENT

35 g of whey protein (7 d/wk) during a 10-wk resistance training program (3 d/wk; 3 sets of 8-12 repetitions with an interval of 1-2 minutes between sets and exercises) involving the leg press, leg extension, and arm flexion exercises. The load will be adjusted weekly.

Leucine-matched collagen

Each participant will be supplemented with collagen (7 d/wk) during 10 weeks.

Group Type: EXPERIMENTAL

Collagen supplementation

Intervention Type: DIETARY_SUPPLEMENT

35 g of collagen (7 d/wk) + 2 g of leucine during a 10-wk resistance training program (3 d/wk; 3 sets of 8-12 repetitions with an interval of 1-2 minutes between sets and exercises) involving the leg press, leg extension, and arm flexion exercises. The load will be adjusted weekly.

Interventions

Whey protein supplementation

35 g of whey protein (7 d/wk) during a 10-wk resistance training program (3 d/wk; 3 sets of 8-12 repetitions with an interval of 1-2 minutes between sets and exercises) involving the leg press, leg extension, and arm flexion exercises. The load will be adjusted weekly.

Intervention Type: DIETARY_SUPPLEMENT

Collagen supplementation

35 g of collagen (7 d/wk) + 2 g of leucine during a 10-wk resistance training program (3 d/wk; 3 sets of 8-12 repetitions with an interval of 1-2 minutes between sets and exercises) involving the leg press, leg extension, and arm flexion exercises. The load will be adjusted weekly.

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

• Men and women aged 18-35 years
• To be eutrophic (not overweight or obese)

Exclusion Criteria

• To present a history of musculoskeletal disorders
• Be attending a systematized weight training program for at least six months
• To make use of medicines that could affect muscle function.
• To have used ergogenic supplements and anabolic steroids for at least six months before study
• To have restrictions for exercises practice considering Physical Activity Readiness Questionnaire (PAR-Q) responses.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 35 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Universidade Estadual de Londrina

OTHER

Sponsor Role: collaborator

Universidade Norte do Paraná

OTHER

Sponsor Role: lead

Responsible Party

Andreo Fernando Aguiar

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Andreo Aguiar

Role: PRINCIPAL_INVESTIGATOR

Universidade Norte do Paraná

Locations

Universidade Norte do Paraná

Londrina, Paraná, Brazil

Countries

Brazil

Other Identifiers

3.058.958

Identifier Type: -

Identifier Source: org_study_id