Effect of Whey Protein Supplementation and Resistance Exercise on Muscle Parameters in Older Adults

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-04-30

Study Completion Date

2011-05-31

Brief Summary

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This research study is looking at the effects of a whey protein nutritional supplement on changes in muscle mass, strength and physical function in response to a 6 month program of strength training exercise.

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Detailed Description

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Conditions

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Mobility Limitation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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A, 1

Group Type ACTIVE_COMPARATOR

Whey protein

Intervention Type DIETARY_SUPPLEMENT

powdered, 46g supplement dissolved in fluids, twice daily

A, 2

Group Type PLACEBO_COMPARATOR

Maltodextrin placebo

Intervention Type DIETARY_SUPPLEMENT

powdered, 46g supplement dissolved in fluids, twice daily

Interventions

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Whey protein

powdered, 46g supplement dissolved in fluids, twice daily

Intervention Type DIETARY_SUPPLEMENT

Maltodextrin placebo

powdered, 46g supplement dissolved in fluids, twice daily

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Male and Females 70-85 yrs
* Community dwelling
* Short Physical Performance Battery score \< 10
* BMI = 21-32.5

Exclusion Criteria

* Acute or terminal illness
* Mini Mental State Exam \< 23
* Myocardial infarction in previous 6 months, symptomatic coronary artery disease, or congestive heart failure
* Upper or lower extremity fracture in previous 6 months
* Uncontrolled hypertension (\>150/90 mm Hg).
* Neuromuscular diseases and drugs which affect neuromuscular function.
* Hormone replacement therapy
* eGFR \<30 mL/min/1.73m2
* Types I and II Diabetes Mellitus
* Dietary protein intake \< 0.8 g.kg-1.day-1
* Disorders of nutrient absorption
* Milk, or whey allergy
* Sulfa drugs and allergy to PABA-containing sunscreens

Minimum Eligible Age

70 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes