Desflurane Versus Isoflurane for Speeding Postanesthetic Recovery and Hospital Discharge

NCT ID: NCT06252207

Last Updated: 2025-08-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

2619 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-12-08

Study Completion Date

2026-12-01

Brief Summary

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The investigators thus propose a comparative effectiveness quality improvement project to evaluate the feasibility of switching from near-exclusive use of isoflurane in adult general surgical patients to Desflurane.

Detailed Description

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The three available volatile anesthetics appear to be comparably safe. However, higher solubility slows emergence from isoflurane and sevoflurane compared to Desflurane. Even a few minutes delay in emergence from anesthesia has financial implications since institutional costs of operating room time can easily be $30 per minute. Postoperative care is also expensive. Furthermore, in busy hospitals such as the Cleveland Clinic, inadequate recovery throughput frequently delays surgery.

The investigators thus propose a comparative effectiveness quality improvement project to evaluate the feasibility of switching from near-exclusive use of isoflurane in adult general surgical patients to Desflurane. (The investigators will exclude children because there are compelling clinical reasons to use sevoflurane in pediatric patients.) The proposed comparison is between isoflurane (our current routine) and Desflurane which is no longer used at the Clinic because of price concerns - a decision that that did not consider down-stream effects, including prolonged emergence and recovery.

Conditions

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Surgery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Randomized cluster cross-over trial
Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants
Patients will not be told which type of volatile anesthetic they received.

Study Groups

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Desflurane

General anesthesia with desflurane.

Group Type EXPERIMENTAL

Desflurane

Intervention Type DRUG

General anesthesia with desflurlane

Isoflurane

General anesthesia with isoflurane.

Group Type EXPERIMENTAL

Isoflurane

Intervention Type DRUG

General anesthesia with isoflurane

Interventions

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Desflurane

General anesthesia with desflurlane

Intervention Type DRUG

Isoflurane

General anesthesia with isoflurane

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Adults having general anesthesia in the G operating room suite at the Cleveland Clinic Main Campus.

Exclusion Criteria

* Operations lasting \<1.5 hours.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Cleveland Clinic

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Allen Keebler, D.O.

Role: PRINCIPAL_INVESTIGATOR

The Cleveland Clinic

Locations

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Cleveland Clinic

Cleveland, Ohio, United States

Site Status

Countries

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United States

Other Identifiers

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23-1049

Identifier Type: -

Identifier Source: org_study_id

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