Effects of Desflurane and Propofol During Lung Volume Reduction Surgery

NCT ID: NCT04226625

Last Updated: 2020-01-13

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE4
• Total Enrollment: 18 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2000-01-31
• Study Completion Date: 2002-03-21

Brief Summary

Patients presenting for lung volume reduction are very high risk patients and it is important they receive the best anesthetic available. This study aims to answer which is the best anesthetic for managing such cases.

Detailed Description

The anesthetic technique for lung volume reduction surgery consists of a thoracic epidural in combination with a general anesthetic. The thoracic epidural is routine for this operation and allows administration of local anesthetics and painkillers in the epidural space which results in profound pain relief in the area of surgery. The epidural is routinely used for pain control during the surgery and after the surgery when the patient is awake.

The general anesthetic used may be a volatile agent (gas for example Desflurane), which is administered through the anesthesia machine, or an intravenous anesthetic agent, which is administered into a vein through an intravenous line as a continuous infusion (example Propofol). The use of an anesthetic agent and an epidural often causes a decrease in blood pressure which is treated with medication. The investigators are comparing the two anesthetic techniques regarding their effect on blood pressure and the amount of medication needed to treat it.

Conditions

Lung Volume Reduction Surgery

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Propofol

Patients will receive Propofol as an intravenous (IV) agent, which is administered into a vein through an IV line as a continuous infusion.

Group Type: ACTIVE_COMPARATOR

Propofol

Intervention Type: DRUG

Intravenous administration

Desflurane

Patients will receive Desflurane as a gas that is administered through an anesthesia machine.

Group Type: ACTIVE_COMPARATOR

Desflurane

Intervention Type: DRUG

Volatile administration

Interventions

Propofol

Intravenous administration

Intervention Type: DRUG

Desflurane

Volatile administration

Intervention Type: DRUG

Other Intervention Names

Diprivan; Suprane

Eligibility Criteria

Inclusion Criteria

• Scheduled to undergo lung volume reduction surgery (LVRS)

Exclusion Criteria

• Does not sign a study consent form

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Columbia University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Bessie Kachulis, MD

Role: PRINCIPAL_INVESTIGATOR

Columbia University

Locations

Columbia University Irving Medical Center

New York, New York, United States

Countries

United States

Other Identifiers

9340

Identifier Type: OTHER

Identifier Source: secondary_id

AAAR3687

Identifier Type: -

Identifier Source: org_study_id