Effect of Total Intravenous Anesthesia and Balanced Anesthesia on Postoperative Lung Function

NCT ID: NCT00706277

Last Updated: 2009-02-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-06-30

Study Completion Date

2008-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of the study is to investigate the effects of total intravenous anesthesia (TIVA; propofol, remifentanil) and balanced anesthesia (BAL; induction with propofol and fentanyl; maintenance of anesthesia with sevoflurane and nitrous oxide) on pulmonary function 30 minutes after emergence from the general anesthesia.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Lung Function

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

TIVA

patients receiving total intravenous anesthesia (TIVA)

Group Type ACTIVE_COMPARATOR

propofol

Intervention Type DRUG

propofol 2mg/kg for induction of anesthesia; followed by propofol 6 mg/kg/hour

remifentanil

Intervention Type DRUG

remifentanil 0,25mcg/kg/hour

balanced

patients receiving balanced anesthesia

Group Type ACTIVE_COMPARATOR

propofol

Intervention Type DRUG

propofol 2mg

fentanyl

Intervention Type DRUG

fentanyl 100mcg

Sevoflurane/Nitrous Oxide

Intervention Type DRUG

maintenance of anesthesia with sevoflurane and nitrous oxide

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

propofol

propofol 2mg/kg for induction of anesthesia; followed by propofol 6 mg/kg/hour

Intervention Type DRUG

propofol

propofol 2mg

Intervention Type DRUG

remifentanil

remifentanil 0,25mcg/kg/hour

Intervention Type DRUG

fentanyl

fentanyl 100mcg

Intervention Type DRUG

Sevoflurane/Nitrous Oxide

maintenance of anesthesia with sevoflurane and nitrous oxide

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* ASA 1-2
* BMI normal

Exclusion Criteria

* lung disease
* Nicotine abuse
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Medical University Innsbruck

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

TILAK A-6020 Innsbruck, Anichstr. 35 AUSTRIA

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Arnulf Benzer, MD

Role: PRINCIPAL_INVESTIGATOR

TILAK Hospitals

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

TILAK Hospitals

Innsbruck, , Austria

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Austria

References

Explore related publications, articles, or registry entries linked to this study.

Gunnarsson L, Lindberg P, Tokics L, Thorstensson O, Thorne A. Lung function after open versus laparoscopic cholecystectomy. Acta Anaesthesiol Scand. 1995 Apr;39(3):302-6. doi: 10.1111/j.1399-6576.1995.tb04066.x.

Reference Type BACKGROUND
PMID: 7793205 (View on PubMed)

Regli A, von Ungern-Sternberg BS, Reber A, Schneider MC. Impact of spinal anaesthesia on peri-operative lung volumes in obese and morbidly obese female patients. Anaesthesia. 2006 Mar;61(3):215-21. doi: 10.1111/j.1365-2044.2005.04441.x.

Reference Type BACKGROUND
PMID: 16480344 (View on PubMed)

Natalini G, Franceschetti ME, Pletti C, Recupero D, Lanza G, Bernardini A. Impact of laryngeal mask airway and tracheal tube on pulmonary function during the early postoperative period. Acta Anaesthesiol Scand. 2002 May;46(5):525-8. doi: 10.1034/j.1399-6576.2002.460509.x.

Reference Type BACKGROUND
PMID: 12027846 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2007-007161-25

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

The BALANCED Anaesthesia Study
NCT02073357 WITHDRAWN NA
Comparison of Sevoflurane and Propofol on ANI
NCT06907823 NOT_YET_RECRUITING NA