Anesthetics to Prevent Lung Injury in Cardiac Surgery

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1/PHASE2

Total Enrollment

51 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-06-09

Study Completion Date

2021-02-01

Brief Summary

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The purpose of this study is to investigate whether the use of inhaled anesthetics, compared to intravenous anesthetics, can affect the amount of lung inflammation and postoperative respiratory complications seen after cardiac surgery.

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Detailed Description

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Randomized, controlled trial involving 45 adult patients undergoing cardiac surgery with cardiopulmonary bypass. Patients will be randomized to receive either inhaled anesthesia with sevoflurane or total intravenous anesthesia (TIVA) with propofol for the maintenance phase of their cardiac anesthetic. Assessment of lung inflammation will take place using fiberoptic bronchoscopic sampling of lung fluid as well as serum collection before and after exposure to cardiopulmonary bypass, and the incidence of compositive postoperative pulmonary complications will take place in the postoperative period.

Conditions

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Inflammatory Lung Injury Ischemia-Reperfusion Lung Injury Postoperative Pulmonary Complications

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Inhaled Anesthesia

Patients in the inhaled anesthesia arm will be given sevoflurane anesthesia maintenance for the duration of the procedure including cardiopulmonary bypass.

Group Type EXPERIMENTAL

Sevoflurane

Intervention Type DRUG

Volatile Anesthetic

Intravenous Anesthesia

Patients in the intravenous anesthesia arm will be given total intravenous anesthesia with propofol for the duration of the procedure including cardiopulmonary bypass.

Group Type ACTIVE_COMPARATOR

Propofol

Intervention Type DRUG

Intravenous Anesthetic

Interventions

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Sevoflurane

Volatile Anesthetic

Intervention Type DRUG

Propofol

Intravenous Anesthetic

Intervention Type DRUG

Other Intervention Names

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Diprivan

Eligibility Criteria

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Inclusion Criteria

* Adult patients (age 18+)
* Undergoing cardiac surgery with cardiopulmonary bypass

Exclusion Criteria

* Emergency surgery
* History of severe COPD, emphysema, or ILD
* Recent (\<2wk) or current use of systemic glucocorticoids
* Prior history of pneumothorax
* Allergy/contraindication to intravenous anesthetics
* Personal or family history of malignant hyperthermia or high risk for malignant hyperthermia

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No