Influence of Postoperative Cognitive Function in Patients With Sevoflurane Postconditioning on Carotid Intima Stripped
NCT ID: NCT04950205
Last Updated: 2021-07-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
EARLY_PHASE1
140 participants
INTERVENTIONAL
2021-06-01
2022-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
SINGLE_GROUP
OTHER
SINGLE
Study Groups
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Sevoflurane post conditioning group（S1）
propofol：0.05～0.1mg/(kg.min) maintain throughout the whole surgery ,1% sevoflurane plus after open Carotid artery until the end of surgery
Sevoflurane inhalant product
propofol plus 1% sevoflurane after open Carotid artery until the end of surgery
The control group（P）
propofol：0.05～0.1mg/(kg.min) maintain throughout the whole surgery without sevoflurane
No interventions assigned to this group
Interventions
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Sevoflurane inhalant product
propofol plus 1% sevoflurane after open Carotid artery until the end of surgery
Eligibility Criteria
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Inclusion Criteria
* Aged between 40 and 80 years
* Patients scheduled for surgery of Carotid stenosis under general anaesthesia
Exclusion Criteria
* Serious heart block or cardiac decompensation or severe sinus slow (HR \< 50 times/min),
* The abnormal nerve monitoring in operation, MMES preoperative score \< 20 points,
* Any rescue unexpected occurred during the operation
50 Years
80 Years
ALL
No
Sponsors
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Second Affiliated Hospital, School of Medicine, Zhejiang University
OTHER
Responsible Party
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Locations
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2nd Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, China
2nd Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, China
Countries
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Central Contacts
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Facility Contacts
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Wang Bin, Master
Role: primary
Other Identifiers
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2021-0107
Identifier Type: -
Identifier Source: org_study_id
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