Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion
NCT ID: NCT00526695
Last Updated: 2008-07-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
10 participants
INTERVENTIONAL
2005-01-31
2008-12-31
Brief Summary
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Study hypothesis: The volatile anesthetic sevoflurane at subanesthetic concentrations achieves endothelial protection against ischemia/reperfusion injury and reduces inflammatory markers in the circulation
Detailed Description
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Forearm perfusion, endothelial function and leukocyte/thrombocyte activation after tourniquet-induced ischemia/reperfusion injury of the forearm are measured using healthy volunteers in a cross-over design.
Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
NONE
Interventions
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Sevoflurane (Preconditioning)
Inhalation of sub-anesthetic doses of sevoflurane
Eligibility Criteria
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Inclusion Criteria
* No asthma
* NPO
* Volunteer
Exclusion Criteria
* Chronic medication
* Asthma
* Smoking
25 Years
45 Years
MALE
Yes
Sponsors
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University of Zurich
OTHER
Responsible Party
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Anesthesiology, Univ. Hospital Zurich
Principal Investigators
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Michael Zaugg, PD Dr. med.
Role: PRINCIPAL_INVESTIGATOR
UniversitaetsSpital Zuerich
Michael Zaugg, PD Dr. med.
Role: PRINCIPAL_INVESTIGATOR
University of Zurich
Locations
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University Hospital of Zurich
Zurich, , Switzerland
Countries
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Central Contacts
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01 Studienregister MasterAdmins
Role: CONTACT
Phone: +41 (0)44 255 11 11
Facility Contacts
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Michael Zaugg, MD
Role: primary
References
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Lucchinetti E, Zeisberger SM, Baruscotti I, Wacker J, Feng J, Zaugg K, Dubey R, Zisch AH, Zaugg M. Stem cell-like human endothelial progenitors show enhanced colony-forming capacity after brief sevoflurane exposure: preconditioning of angiogenic cells by volatile anesthetics. Anesth Analg. 2009 Oct;109(4):1117-26. doi: 10.1213/ANE.0b013e3181b5a277.
Other Identifiers
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17-2005
Identifier Type: -
Identifier Source: org_study_id