Preconditioning With Sevoflurane and Propofol in Patients Undergoing Minimally Invasive Mitral Valve Surgery
NCT ID: NCT02551328
Last Updated: 2015-09-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
UNKNOWN
48 participants
OBSERVATIONAL
2015-06-30
2016-09-30
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Evaluate the Protective Effect of Conditioning With Sevoflurane on the Myocardium
NCT02851433
Sevoflurane in Cardiac Surgery
NCT00821262
Comparison of Propofol and Sevoflurane as a Primary Anesthetic for Cardiac Ablation of Atrial Fibrillation.
NCT02697448
Remote Preconditioning and Myocardial Protection
NCT02877238
Effect of Anesthetics on Microcirculation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery
NCT03209193
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
* Volatile conditioning (sevoflurane) used during induction (preconditioning) and during the operation as maintenance (perconditioning) and no propofol.
* Propofol induction and maintenance (TIVA) and no volatile anaesthetics.
Outlet/residual blood samples coming from routine check will be collected at different time points.
Study will be powered on Troponin I (primary statistical outcome). Original secondary outcome will be considered: platelets activation, left ventricle function, clinical figures (length of stay, inotrops requirements, ventilation times and other relevant).
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
CASE_CONTROL
PROSPECTIVE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Sevofluorane
Patients preconditioned with Sevo
sevofluorane
Continuous infusion of sevofluorane
Propofol
Patients with no preconditioning
No interventions assigned to this group
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
sevofluorane
Continuous infusion of sevofluorane
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
2. Patients undergoing elective (or urgent) first-time minimal invasive mitral valve surgery.
Exclusion Criteria
2. Renal failure (with a GFR \< 30 ml/min/1.73m2),
3. Glibenclamide or nicorandil (as these medications may interfere with VC)
4. Pregnancy
5. Known intolerance/allergy to sevoflurane or propofol
18 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Fondazione Toscana Gabriele Monasterio
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
MOSCARELLI MARCO
MD, PhD
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Paolo Del Sarto, MD
Role: PRINCIPAL_INVESTIGATOR
Fondazione Toscana Gabriele Monasterio
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Ospedale del cuore, Pasquinucci Hospital, Fondazione Monasterio
Massa, Italy, Italy
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
452/2014
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.