One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

76 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-10-31

Study Completion Date

2007-09-30

Brief Summary

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One-lung ventilation; organ protection; volatile anesthetics

One-lung ventilation has become a common procedure for thoracoscopic surgery. Two hypothesis will be tested in this study:

1. Are inflammatory mediators increased in the re-ventilated lung after short-period pulmonary collapse?
2. Does Sevoflurane influence the production of inflammatory mediators in the re-inflated lung? Therefore, this study will elucidate the potential protective effect of a volatile anaesthetic (sevoflurane) on the production of inflammatory mediators by the respiratory compartment of the lung, i.e. the alveolar epithelium.

* Trial with immunomodulatory product / biological

Detailed Description

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Conditions

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Thoracic Surgery With One-lung Ventilation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Interventions

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Sevoflurane/propofol

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Thoracic surgery (thoracotomy, thoracoscopy) with one-lung ventilation

Exclusion Criteria

* Immunosuppressive therapy
* Ongoing inflammatory processes

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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University of Zurich

Principal Investigators

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01 Studienregister MasterAdmins

Role: STUDY_DIRECTOR

UniversitaetsSpital Zuerich

Locations

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University Hospital of Zurich

Zurich, , Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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StV 20-2004

Identifier Type: -

Identifier Source: org_study_id