Sevoflurane vs Nitrous Oxide Inhalation at Subanesthetic Concentrations - 11

NCT ID: NCT00000259

Last Updated: 2015-05-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

1996-08-31

Study Completion Date

1997-11-30

Brief Summary

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The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To examine sevoflurane versus isoflurane inhalation at subanesthetic concentrations on mood, pain, and psychomotor performance.

Detailed Description

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Conditions

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Opioid-Related Disorders Substance-Related Disorders

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Placebo

Subject inhales no drug (100% oxygen)

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

0.3% sevoflurane

Group Type ACTIVE_COMPARATOR

0.3 % Sevoflurane

Intervention Type DRUG

0.6% sevoflurane

Group Type ACTIVE_COMPARATOR

0.6% Sevoflurane

Intervention Type DRUG

15% Nitrous oxide

Group Type ACTIVE_COMPARATOR

15 % Nitrous oxide

Intervention Type DRUG

30% Nitrous oxide

Group Type ACTIVE_COMPARATOR

30% Nitrous oxide

Intervention Type DRUG

Interventions

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15 % Nitrous oxide

Intervention Type DRUG

0.3 % Sevoflurane

Intervention Type DRUG

30% Nitrous oxide

Intervention Type DRUG

0.6% Sevoflurane

Intervention Type DRUG

Placebo

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

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Minimum Eligible Age

21 Years

Maximum Eligible Age

39 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute on Drug Abuse (NIDA)

NIH

Sponsor Role collaborator

University of Chicago

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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James Zacny, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Chicago

Locations

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University of Chicago, Anesthesia & Critical Care

Chicago, Illinois, United States

Site Status

Countries

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United States

References

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Anesthesiology. 1997 (in press).

Reference Type BACKGROUND

Other Identifiers

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R01DA008391

Identifier Type: NIH

Identifier Source: secondary_id

View Link

R01-08391-11

Identifier Type: -

Identifier Source: secondary_id

NIDA-08391-11

Identifier Type: -

Identifier Source: org_study_id

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