1-1-8 Wash-in for Sevoflurane Low Flow Anesthesia

NCT ID: NCT03510013

Last Updated: 2018-08-08

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 100 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-04-01
• Study Completion Date: 2018-05-31

Brief Summary

The investigators propose a new wash-in technique for sevoflurane low flow anesthesia with fresh gas flow of O2:N2O or O2:air 1:1 L/min with sevoflurane 8%.

The objective of this study is to identify time to achieve alveolar concentration of sevoflurane at 1, 1.5, 2, 2.5, 3, and 3.5%

Detailed Description

The benefits of low flow anesthesia are economic, less pollution, more heat and humidity preservation but it requires appropriate wash-in phase. The current wash-in protocols for sevoflurane are complicated and time consuming. The investigators propose a new 1-1-8 sevoflurane wash-in protocol which is more simple and predictable.

The objective of this study is to identify time to achieve alveolar concentration of sevoflurane at 1, 1.5, 2, 2.5, 3, and 3.5% with 1-1-8 wash-in protocol.

All patients will receive iv propofol 2 mg/kg as induction agent and succinyl choline 1.5 mg/kg for intubation. Then the ventilation will be controlled to achieve end-tidal CO2 30-35 mmHg with O2:N2O or O2:air 1:1 L/min with sevoflurane 8%. Time to achieve alveolar concentration of sevoflurane at 1, 1.5, 2, 2.5, 3, and 3.5% will be recorded and analyzed. After that, the concentration of sevoflurane and anesthetic technique will be adjusted to requirement of anesthesiologist.

Conditions

Anesthesia

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

1-1-8 wash-in

Wash-in using O2:N2O or O2:air 1:1 L/min with sevoflurane 8%

Group Type: EXPERIMENTAL

1-1-8 wash-in

Intervention Type: PROCEDURE

wash-in phase during start of low flow anesthesia

Sevoflurane

Intervention Type: DRUG

Drug used for wash-in protocol

Interventions

1-1-8 wash-in

wash-in phase during start of low flow anesthesia

Intervention Type: PROCEDURE

Sevoflurane

Drug used for wash-in protocol

Intervention Type: DRUG

Other Intervention Names

Inhalation anesthetic

Eligibility Criteria

Inclusion Criteria

• ASA classification I-II
• age 18-65 years

Exclusion Criteria

• BMI > 35
• contraindicated for N2O
• • with pulmonary or cardiac disease

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Khon Kaen University

OTHER

Sponsor Role: lead

Responsible Party

Thepakorn Sathitkarnmanee

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Thepakorn Sathitkarnmanee, MD

Role: PRINCIPAL_INVESTIGATOR

Faculty of Medicine, Khon Kaen University

Locations

Faculty of Medicine, Khon Kaen University

Khon Kaen, , Thailand

Countries

Thailand

References

Tribuddharat S, Sathitkarnmanee T, Vattanasiriporn N, Thananun M, Nonlhaopol D, Somdee W. 1-1-8 one-step sevoflurane wash-in scheme for low-flow anesthesia: simple, rapid, and predictable induction. BMC Anesthesiol. 2020 Jan 24;20(1):23. doi: 10.1186/s12871-020-0940-2.

Reference Type: DERIVED

PMID: 31980020 (View on PubMed)

Other Identifiers

HE601228

Identifier Type: -

Identifier Source: org_study_id