Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide - 3
NCT ID: NCT00000251
Last Updated: 2015-12-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE2
10 participants
INTERVENTIONAL
1994-04-30
1996-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
SINGLE
Study Groups
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Placebo
Subjects inhale 100% oxygen
100% oxygen
Placebo
30% N2O
Subjects inhale 30% N2O
30% N2O
0.2% isoflurane
Subjects inhale 0.2% isoflurane
0.2% isoflurane
0.4% isoflurane
Subjects inhale 0.4% isoflurane
0.4% isoflurane
0.2% isoflurane + 30% N2O
Subjects will inhale a combination of 0.2% isoflurane and 30% N2O
30% N2O
0.2% isoflurane
0.4% isoflurane + 30% N2O
Subjects will inhale a combination of 0.4% isoflurane and 30% N2O
30% N2O
0.4% isoflurane
Interventions
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30% N2O
0.2% isoflurane
0.4% isoflurane
100% oxygen
Placebo
Eligibility Criteria
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Inclusion Criteria
21 Years
32 Years
ALL
Yes
Sponsors
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National Institute on Drug Abuse (NIDA)
NIH
University of Chicago
OTHER
Responsible Party
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Principal Investigators
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James Zacny, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
University of Chicago
Locations
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University of Chicago, Anesthesia & Critical Care
Chicago, Illinois, United States
Countries
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References
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Zacny JP, Yajnik S, Lichtor JL, Klafta JM, Young CJ, Thapar P, Rupani G, Coalson DW, Apfelbaum JL. The acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations on cognitive and psychomotor performance in healthy volunteers. Anesth Analg. 1996 Jan;82(1):153-7. doi: 10.1097/00000539-199601000-00028.
Whelan J, Hackshaw A, McTiernan A, Grimer R, Spooner D, Bate J, Ranft A, Paulussen M, Juergens H, Craft A, Lewis I. Survival is influenced by approaches to local treatment of Ewing sarcoma within an international randomised controlled trial: analysis of EICESS-92. Clin Sarcoma Res. 2018 Mar 30;8:6. doi: 10.1186/s13569-018-0093-y. eCollection 2018.
Other Identifiers
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R01-08391-3
Identifier Type: -
Identifier Source: secondary_id
NIDA-08391-3
Identifier Type: -
Identifier Source: org_study_id