Role of Volatile Anesthetics for Hepatic Protection

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2006-03-31

Study Completion Date

2007-12-31

Brief Summary

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This study aims to evaluate the attenuation of ischemic-reperfusion injury in the liver after sevoflurane preconditioning. In the presence of sevoflurane, an attenuation of liver injury is hypothesized (diminished increase of liver enzymes, reduced production of inflammatory mediators).

Detailed Description

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Organ protection; preconditioning; volatile anesthetics; ischemia reperfusion

Conditions

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Reperfusion Injury

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Interventions

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Sevoflurane

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Older than 18 years of age
* Patients undergoing liver resection (benign or malignant tumors)

Exclusion Criteria

* Laparoscopic liver resection coagulopathy (platelets \< 50,000/ml, Quick \< 50%)
* Liver cirrhosis

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Principal Investigators

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01 Studienregister MasterAdmins

Role: STUDY_DIRECTOR

UniversitaetsSpital Zuerich

Locations

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University Hospital of Zurich

Zurich, , Switzerland

Site Status

Countries

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Switzerland

References

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Beck-Schimmer B, Breitenstein S, Urech S, De Conno E, Wittlinger M, Puhan M, Jochum W, Spahn DR, Graf R, Clavien PA. A randomized controlled trial on pharmacological preconditioning in liver surgery using a volatile anesthetic. Ann Surg. 2008 Dec;248(6):909-18. doi: 10.1097/SLA.0b013e31818f3dda.

Reference Type DERIVED

PMID: 19092335 (View on PubMed)

Other Identifiers

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StV 5-2006

Identifier Type: -

Identifier Source: org_study_id