Effects of Sevoflurane Versus Desflurane Anesthesia Under Protective Mechanical Ventilation for Robotic Assisted Surgery

NCT ID: NCT07304479

Last Updated: 2025-12-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-05-01

Study Completion Date

2026-02-28

Brief Summary

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Inhalational anesthetics, when used in abdominal surgery, offer advantages of lung protection and reduced alveolar inflammation. There is little literature, however, in the comparative use of sevoflurane versus desflurane anesthesia in patients undergoing abdominal robotic-assisted surgery and their effects on lung mechanics.

Detailed Description

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Conditions

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Respiratory Mechanics Intraoperative

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Sevoflurane (Volatile Anesthetic)

Group Type ACTIVE_COMPARATOR

Sevoflurane (Volatile Anesthetic)

Intervention Type DRUG

Sevoflurane for robotic assisted laparoscopic surgery

Deslfurane (Volatile Anesthetic)

Group Type ACTIVE_COMPARATOR

Desflurane (volatile anesthetic)

Intervention Type DRUG

Desflurane for robotic assisted laparoscopic surgery

Interventions

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Sevoflurane (Volatile Anesthetic)

Sevoflurane for robotic assisted laparoscopic surgery

Intervention Type DRUG

Desflurane (volatile anesthetic)

Desflurane for robotic assisted laparoscopic surgery

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Age 18 to 87 years
* Undergoing elective robotic-assisted abdominal surgery
* ASA physical status I-III

Exclusion Criteria

* ASA IV or V
* Emergency surgery
* Renal insufficiency
* Clinically significant respiratory disease
* Cardiomyopathy
* Uncontrolled hypertension
Minimum Eligible Age

18 Years

Maximum Eligible Age

87 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National and Kapodistrian University of Athens

OTHER

Sponsor Role lead

Responsible Party

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Aliki Tympa

Assistant Professor of Anesthesiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Aikaterini Melemeni, Professor

Role: STUDY_DIRECTOR

Aretaieion University Hospital, National And Kapodistrian University Of Athens

Locations

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Aretaieion University Hospital

Athens, , Greece

Site Status RECRUITING

Countries

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Greece

Central Contacts

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Aliki Tympa, MD,PhD

Role: CONTACT

Phone: 00306955487575

Email: [email protected]

Facility Contacts

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Aliki Tympa, MD,PhD

Role: primary

Aikaterini Melemeni, Professor

Role: backup

References

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Herling SF, Dreijer B, Wrist Lam G, Thomsen T, Moller AM. Total intravenous anaesthesia versus inhalational anaesthesia for adults undergoing transabdominal robotic assisted laparoscopic surgery. Cochrane Database Syst Rev. 2017 Apr 4;4(4):CD011387. doi: 10.1002/14651858.CD011387.pub2.

Reference Type RESULT
PMID: 28374886 (View on PubMed)

Other Identifiers

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705/25-07-2025

Identifier Type: -

Identifier Source: org_study_id