Comparison of Sevoflurane and Propofol on ANI

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-30

Study Completion Date

2025-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The goal of this clinical trial is to compare the effect of sevoflurane and propofol on analgesia nociception index(ANI) in patients undergoing general anesthesia. The main question it aims to answer is whether propofol anesthesia results in lesser ANI change to a nociceptive stimulation compared to sevoflurane.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Comparation Analgesia Efficiency With Propofol Combine Sevoflurane vs Propofol

NCT03841812

Nociceptive Pain Analgesic Adverse Reaction Inhalant Use

COMPLETED PHASE3

Comparison of Analgesic Effect of Volatile Anesthetics

NCT02830243

Anesthesia

COMPLETED PHASE3

A Comparison of Propofol Based Total Intravenous Anesthesia and Sevoflurane Based Balanced Anesthesia on Renal Protection During Lung Transplantation Under Extracorporeal Membrane Oxygenation - A Prospective, Randomized Trial

NCT02009280

Patients Undergoing Lung Transplantation Under Extracorporeal Membrane Oxygenation

COMPLETED PHASE4

Postoperative Effects of Propofol Versus Sevoflurane Anesthesia

NCT05935930

General Anesthetic Drug Adverse Reaction

COMPLETED PHASE4

The Different Analgesic Potency of Volatile Anesthetics at Equi-MAC

NCT02609802

Orthopedic Disorders

COMPLETED PHASE3

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Patients will be allocated to either propofol or sevoflurane group. Nociceptive event will be defined as long-lasting tetanic stimulation, square-wave, duration of 30 seconds , amplitude of 50mA, frequency of 50 Hz. analgesia nociception index value and hemodynamic parameters will be recorded 1-minute before and after nociceptive event.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Propofol Sevoflurane Analgesia Nociception Index

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Sevoflurane

Group Type OTHER

Sevoflurane

Intervention Type DRUG

sevoflurane anesthesia

Propofol

Group Type OTHER

propofol

Intervention Type DRUG

propofol anesthesia

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

propofol

propofol anesthesia

Intervention Type DRUG

Sevoflurane

sevoflurane anesthesia

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* American society of anesthesiologists physical status class I or II

Exclusion Criteria

* history of drugs that can affect the central nervous system and autonomic nervous system, such as anticholinergics, betablockers, antidepressants..etc.
* history of allergic reaction to sevoflurane and/or propofol
* history of and/or family history of malignant hyperthermia
* neurodegenerative disorder
* psychiatric disorder
* arrhythmia
* diabetes mellitus
* drug abuse history

Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No