Three Anaesthesic Method in Electroconvulsive Theraphy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

39 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-01-31

Study Completion Date

2011-08-31

Brief Summary

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To compare the effectiveness of three different anesthetic regimens (propofol, remifentanil-propofol and sevoflurane in ECT.

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Detailed Description

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The purpose of this study is to compare the effectiveness of three different anesthetic regimens (propofol, remifentanil-propofol and sevoflurane) with respect to seizure duration, postictal suppression index, early and midictal amplitude, hemodynamic variables and recovery profiles in ECT.

Conditions

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Anesthesia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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propofol (Group P)

The patients in Group P received 1 mg/kg propofol IV (over 15 sec) during anesthesia induction

Group Type PLACEBO_COMPARATOR

Propofol

Intervention Type DRUG

1 mg/kg propofol IV (over 15 sec) during anesthesia induction

remifentanil and propofol (Group R)

Patients in Group R received remifentanil 1 µg/kg IV (over 60 sec) and 0.5 mg/kg propofol IV (over 15 sec)during anesthesia induction

Group Type ACTIVE_COMPARATOR

Remifentanil and propofol

Intervention Type DRUG

1 µg/kg IV (over 60 sec)remifentanil and 0.5 mg/kg propofol IV (over 15 sec)during anesthesia induction

sevoflurane (Group S)

In Group S, sevoflurane was started at 6% for induction and continued at 1% until the electrical stimulus was delivered, at which time it was stopped.

Group Type ACTIVE_COMPARATOR

Sevoflurane

Intervention Type DRUG

Sevoflurane was started at 6% for induction and continued at 1% until the electrical stimulus was delivered

Interventions

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Propofol

1 mg/kg propofol IV (over 15 sec) during anesthesia induction

Intervention Type DRUG

Remifentanil and propofol

1 µg/kg IV (over 60 sec)remifentanil and 0.5 mg/kg propofol IV (over 15 sec)during anesthesia induction

Intervention Type DRUG

Sevoflurane

Sevoflurane was started at 6% for induction and continued at 1% until the electrical stimulus was delivered

Intervention Type DRUG

Other Intervention Names

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Intravenous anesthetic agent Opioid and intravenous anesthetic agent Volatil anesthetic

Eligibility Criteria

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Inclusion Criteria

* Upremedicated ASA I-II (American Society of Anesthesiologists's physical status) patients,
* Patients scheduled for six ECT sessions for a variety of psychiatric conditions (major depression, schizophrenia)

Exclusion Criteria

* Involuntary patient status
* Patients with known or self-declared needle or mask phobia
* Pregnancy
* Asthma
* Cerebrovascular disease,
* History of myocardial infarction in the previous 6 months,
* Atrial fibrillation or flutter,heart block,
* A known or family history of reactions to the study drugs.

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No