Study Results
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Basic Information
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COMPLETED
PHASE4
75 participants
INTERVENTIONAL
2016-07-31
2017-02-28
Brief Summary
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In Groups II, 2,75 mg/kg propofol and 0,41 mg/kg ketamine will apply at anaesthesia induction. General anaesthesia will be performed with 6,7/1 ratio of ketamine-propofol mixture with %80 of Mcfarlan dose regiment.
In Groups III, 3 mg/kg propofol and 0,3 mg/kg ketamine will apply at anaesthesia induction. General anaesthesia will be performed with 10/1 ratio of ketamine-propofol mixture with %90 of Mcfarlan dose regiment.
After than surgical operation recovery time, PAED scores, FLACC scores, Staying time in PACU will be recorded. These data will be evaluated with statistically.
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Detailed Description
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In Groups II, 2,75 mg/kg propofol and 0,41 mg/kg ketamine will apply at anaesthesia induction. General anaesthesia will be performed with 6,7/1 ratio of ketamine-propofol mixture with %80 of Mcfarlan dose regiment.
In Groups III, 3 mg/kg propofol and 0,3 mg/kg ketamine will apply at anaesthesia induction. General anaesthesia will be performed with 10/1 ratio of ketamine-propofol mixture with %90 of Mcfarlan dose regiment.
McFarlan dose regiments include 15 mg/kg/h infusion during 15 minutes, 13 mg/kg/h infusion during second 15 minutes, 11 mg/kg/h infusion from 30 to 60 minutes, 10 mg/kg/h from 1 to 2 h.
Anaesthesia dept will be detect with BIS monitoring during operation. After than surgical operation recovery time, PAED scores, FLACC scores, staying time in PACU and extubation time will be record. At the end of the study, these data will be evaluated with statistically.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
PREVENTION
SINGLE
Study Groups
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ketamine-propofol mixture 5/1
Ketamine-propofol mixture will be compare for every groups.
Ketamine-propofol mixture
Ratio of Ketamine-propofol mixture will be compare for every groups.
ketamine-propofol mixture 10/1
Ketamine-propofol mixture will be compare for every groups.
Ketamine-propofol mixture
Ratio of Ketamine-propofol mixture will be compare for every groups.
Ketamine-propofol mixture 6,7/1
Ketamine-propofol mixture will be compare for every groups
Ketamine-propofol mixture
Ratio of Ketamine-propofol mixture will be compare for every groups.
Interventions
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Ketamine-propofol mixture
Ratio of Ketamine-propofol mixture will be compare for every groups.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Children who will be performed to adenoidectomy and tonsillectomy surgical operations
Exclusion Criteria
* Patients over the age of 13
3 Years
12 Years
ALL
No
Sponsors
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Cukurova University
OTHER
Responsible Party
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ebru biricik
Principal Investigator
Principal Investigators
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Dilek Özcengiz, Professor
Role: STUDY_DIRECTOR
Cukurova University
Locations
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Cukurova University
Adana, Sarıçam, Turkey (Türkiye)
Countries
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References
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Biricik E, Karacaer F, Gulec E, Surmelioglu O, Ilginel M, Ozcengiz D. Comparison of TIVA with different combinations of ketamine-propofol mixtures in pediatric patients. J Anesth. 2018 Feb;32(1):104-111. doi: 10.1007/s00540-017-2438-8. Epub 2017 Dec 16.
Other Identifiers
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Ketamine-Propofol
Identifier Type: -
Identifier Source: org_study_id
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