Power Spectral Analysis of EEG During Equi-MAC Inhalation Anesthesia

NCT ID: NCT02872389

Last Updated: 2020-09-03

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE3
• Total Enrollment: 90 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-08-16
• Study Completion Date: 2016-12-06

Brief Summary

The purpose of this clinical trial is to compare hypnotic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using power spectral analysis of the electroencephalogram.

Detailed Description

Volatile anesthetics vary in their relative hypnotic potency. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different spectral entropy or bispectral index values. However, there were no studies that demonstrate the difference of hypnotic potency using power spectral analysis of electroencephalographic signals (e.g., spectral edge frequency 95%, total power, % value of each bandage). The purpose of this clinical trial is to compare hypnotic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using power spectral analysis of the electroencephalogram.

Conditions

Anesthesia

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: TRIPLE

Study Groups

Sevoflurane

Anesthesia was maintained with sevoflurane.

Group Type: EXPERIMENTAL

Sevoflurane

Intervention Type: DRUG

Anesthesia was maintained with sevoflurane in patients undergoing arthroscopic knee surgery under general anesthesia. End-tidal concentration of sevoflurane was maintained at age-corrected 1 minimum alveolar concentration throughout the study period.

Desflurane

Anesthesia was maintained with desflurane.

Group Type: EXPERIMENTAL

Desflurane

Intervention Type: DRUG

Anesthesia was maintained with desflurane in patients undergoing arthroscopic knee surgery under general anesthesia. End-tidal concentration of desflurane was maintained at age-corrected 1 minimum alveolar concentration throughout the study period.

Interventions

Sevoflurane

Anesthesia was maintained with sevoflurane in patients undergoing arthroscopic knee surgery under general anesthesia. End-tidal concentration of sevoflurane was maintained at age-corrected 1 minimum alveolar concentration throughout the study period.

Intervention Type: DRUG

Desflurane

Anesthesia was maintained with desflurane in patients undergoing arthroscopic knee surgery under general anesthesia. End-tidal concentration of desflurane was maintained at age-corrected 1 minimum alveolar concentration throughout the study period.

Intervention Type: DRUG

Other Intervention Names

SEVO; DES

Eligibility Criteria

Inclusion Criteria

• patients undergoing arthroscopic knee surgery under general anesthesia using volatile anesthetics
• patients with american society of anesthesiologist physical status I, II
• patients aged 19-65 years
• patients obtaining written informed consent

Exclusion Criteria

• patients with a history of any psychiatric or neurological disease
• patients who had received any medication affecting the central nervous system
• patients who had received medication affecting the sympathetic or parasympathetic nervous systems
• patients undergoing tracheal intubation for airway management
• pregnant women

• Minimum Eligible Age: 19 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Kangbuk Samsung Hospital

OTHER

Sponsor Role: lead

Responsible Party

Kyoung-Ho Ryu, MD

Clinical assistant professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Kyoungho Ryu, M.D.

Role: PRINCIPAL_INVESTIGATOR

Kangbuk Samsung Hospital

Locations

Kangbuk Samsung Hospital

Seoul, , South Korea

Countries

South Korea

Other Identifiers

KBSMC 2016-07-033

Identifier Type: -

Identifier Source: org_study_id