Hemodynamics for Equi-MAC Anesthesia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-06-18

Study Completion Date

2018-11-13

Brief Summary

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The aim of this study is to compare the peripheral perfusion index values produced by equi-MAC of sevoflurane and desflurane in patients undergoing single-agent inhalation anesthesia.

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Detailed Description

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Ether derivative anesthetics, including sevoflurane and desflurane, have direct activity on vascular tissue and both are vasodilators. However, there has been no direct comparison of vasodilative effect between sevoflurane and desflurane in vivo in humans. Peripheral perfusion index derived from photoplethysmographic waveform reflects peripheral vasomotor tone. Therefore, the purpose of this study is to compare the peripheral perfusion index values produced by sevoflurane and desflurane at equipotent concentration in patients undergoing single-agent inhalation anesthesia.

Conditions

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Anesthesia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Sevoflurane

Anesthesia is maintained with sevoflurane.

Group Type EXPERIMENTAL

Sevoflurane

Intervention Type DRUG

End-tidal concentration of sevoflurane is maintained at age-corrected 1.0 minimum alveolar concentration throughout the study period.

Desflurane

Anesthesia is maintained with desflurane.

Group Type EXPERIMENTAL

Desflurane

Intervention Type DRUG

End-tidal concentration of desflurane is maintained at age-corrected 1.0 minimum alveolar concentration throughout the study period.

Interventions

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Sevoflurane

End-tidal concentration of sevoflurane is maintained at age-corrected 1.0 minimum alveolar concentration throughout the study period.

Intervention Type DRUG

Desflurane

End-tidal concentration of desflurane is maintained at age-corrected 1.0 minimum alveolar concentration throughout the study period.

Intervention Type DRUG

Other Intervention Names

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Sevorane Suprane

Eligibility Criteria

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Inclusion Criteria

* patients aged between 19 and 65 yr
* patients with American Society of Anesthesiologists physical status classification I or II
* patients scheduled for elective arthroscopic knee surgery under general anesthesia
* patients obtaining written informed consent

Exclusion Criteria

* patients with a history of any disease associated with the autonomic nervous system
* patients receiving any medication affecting the sympathetic or parasympathetic nervous systems
* patients with cardiac arrhythmia, diabetes mellitus, and alcohol or drug abuse
* pregnant women

Minimum Eligible Age

19 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No