Effect of Remifentanil on Cough During Emergence From General Anesthesia : Trial to Compare Between Sevoflurane Anesthesia and Propofol Anesthesia
NCT ID: NCT01240109
Last Updated: 2011-05-13
Study Results
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Basic Information
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COMPLETED
PHASE4
70 participants
INTERVENTIONAL
2010-09-30
2011-02-28
Brief Summary
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Detailed Description
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It has been demonstrated that opioid, intravenous or topical lidocaine administration can attenuate the coughing reflex.
Administered the opioid before emergence, it is effective to prevent cough reflex but the recovery is delayed, it was difficult to predict emergence.
However, remifentanil is an opioid widely used because of rapid context-sensitive half-life, target-controled infusion method to adequately maintain the effect site concentration could help to predict the recovery time to the alert state from the general anesthesia. It is considered proper method of continuous infusion of remifentanil for reducing emergence cough.
Recent reporters suggest that antitussive effect of remifentanil differs depend on main anesthetic agents, the incidence of coughing when tracheal extubation is reduced after propofol anesthesia compared with sevoflurane anesthesia.
However, these studies raise important questions about failure of maintaining the same effect site concentration of remifentanil in both groups.
The objective of this study was to compare the effect of remifentanil on suppression cough reflex during emergence in patient anesthetized using either propofol or sevoflurane additionally under infusion of the identical concentration of remifentanil.
During recovery from general anesthesia the stimuli of endotracheal tube lead to the coughing, hypertension, tachycardia, which can cause a serious complication.
It has been demonstrated that opioid, intravenous or topical lidocaine administration can attenuate the coughing reflex.
Administered the opioid before emergence, it is effective to prevent cough reflex but the recovery is delayed, it was difficult to predict emergence.
However, remifentanil is an opioid widely used because of rapid context-sensitive half-life, target-controled infusion method to adequately maintain the effect site concentration could help to predict the recovery time to the alert state from the general anesthesia. It is considered proper method of continuous infusion of remifentanil for reducing emergence cough.
Recent reporters suggest that antitussive effect of remifentanil differs depend on main anesthetic agents, the incidence of coughing when tracheal extubation is reduced after propofol anesthesia compared with sevoflurane anesthesia.
However, these studies raise important questions about failure of maintaining the same effect site concentration of remifentanil in both groups.
The objective of this study was to compare the effect of remifentanil on suppression cough reflex during emergence in patient anesthetized using either propofol or sevoflurane additionally under infusion of the identical concentration of remifentanil.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
DOUBLE
Study Groups
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propofol
Remifentanil
* propofol group : propofol effect site-TCI 2-4mcg/ml + remifentanil effect site-TCI 2-4ng/ml
* sevoflurane group: sevoflurane end-tidal concentration 0.5-1.0 MAC + remifentanil effect site-TCI 2-4ng/ml
sevoflurane
Remifentanil
* propofol group : propofol effect site-TCI 2-4mcg/ml + remifentanil effect site-TCI 2-4ng/ml
* sevoflurane group: sevoflurane end-tidal concentration 0.5-1.0 MAC + remifentanil effect site-TCI 2-4ng/ml
Interventions
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Remifentanil
* propofol group : propofol effect site-TCI 2-4mcg/ml + remifentanil effect site-TCI 2-4ng/ml
* sevoflurane group: sevoflurane end-tidal concentration 0.5-1.0 MAC + remifentanil effect site-TCI 2-4ng/ml
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* ASA I-II
* aged between 20 and 70 year
* general anesthesia for elective thyroidectomy
Exclusion Criteria
* risk factors for perioperative aspiration
* smoking for recent 8 weeks
* URI or sore throat for recent 2 weeks
* potential of pregnancy
20 Years
70 Years
FEMALE
Yes
Sponsors
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Yonsei University
OTHER
Responsible Party
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Severance Hospital, Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute
Principal Investigators
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Jeong-Rim Lee, MD, Ph.D
Role: PRINCIPAL_INVESTIGATOR
Severance Hospital, Department of Anesthesiology and Pain Medicine
Locations
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Severance Hospital
Seoul, , South Korea
Countries
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Other Identifiers
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4-2010-0369
Identifier Type: -
Identifier Source: org_study_id
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