Dose-dependent Effect of Fentanyl on Cough Attenuation During Emergence From General Anaesthesia
NCT ID: NCT01308320
Last Updated: 2011-03-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
42 participants
INTERVENTIONAL
2010-02-28
2010-07-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
TRIPLE
Study Groups
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saline
control group
saline
According to the enrolled group, certain dose of saline is intravenously administered by bolus just after sevoflurane discontinuation.
F1 group
F1 group : fentanyl 1 mcg/kg
fentanyl citrate
According to the enrolled group, certain dose of fentanyl is intravenously administered by bolus just after sevoflurane discontinuation.
F1.5 group
F1.5 group : fentanyl 1.5 mcg/kg
fentanyl citrate
According to the enrolled group, certain dose of fentanyl is intravenously administered by bolus just after sevoflurane discontinuation.
F2 group
F2 group : fentanyl 2 mcg/kg
fentanyl citrate
According to the enrolled group, certain dose of fentanyl is intravenously administered by bolus just after sevoflurane discontinuation.
Interventions
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fentanyl citrate
According to the enrolled group, certain dose of fentanyl is intravenously administered by bolus just after sevoflurane discontinuation.
saline
According to the enrolled group, certain dose of saline is intravenously administered by bolus just after sevoflurane discontinuation.
Eligibility Criteria
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Inclusion Criteria
* ASA I-II.
* 20-59 years old.
* female only.
Exclusion Criteria
* risks for perioperative pulmonary aspiration.
* history of chronic respiratory disease.
* recent upper respiratory track infection.
* previous and recent smoking history
20 Years
59 Years
FEMALE
No
Sponsors
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Yonsei University
OTHER
Responsible Party
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Severance Hospital, Department of Anesthesiology and Pain Medicine in Yonsei University College of Medicine
Locations
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Severance Hospital
Seoul, , South Korea
Countries
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References
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Tagaito Y, Isono S, Nishino T. Upper airway reflexes during a combination of propofol and fentanyl anesthesia. Anesthesiology. 1998 Jun;88(6):1459-66. doi: 10.1097/00000542-199806000-00007.
Nishina K, Mikawa K, Maekawa N, Obara H. Fentanyl attenuates cardiovascular responses to tracheal extubation. Acta Anaesthesiol Scand. 1995 Jan;39(1):85-9. doi: 10.1111/j.1399-6576.1995.tb05597.x.
Other Identifiers
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4-2009-0111
Identifier Type: -
Identifier Source: org_study_id
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